Abstract
Primary cilia are microtubule-based organelles for sensing of the extracellular milieu and transducing this information into the cell through a variety of molecular signaling pathways. Functioning of the primary cilium has been recently connected to autophagy, a pathway for degradation of cellular components in lysosomes. Autophagy regulates the length of the cilia by removing proteins required for ciliogenesis, a phenomenon that is molecularly different if performed by basal autophagy or when autophagy is induced in response to various stressors. Here we review the current knowledge about the dual interaction between autophagy and ciliogenesis, and discuss the potential role that deregulated ciliary autophagy could have in pathologies with alterations in autophagy and ciliogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Current Opinion in Cell Biology |
| Volume | 39 |
| DOIs | |
| State | Published - Apr 1 2016 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
Autophagy and primary cilia : Dual interplay. / Pampliega, Olatz; Cuervo, Ana Maria.
In: Current Opinion in Cell Biology, Vol. 39, 01.04.2016, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autophagy and primary cilia
T2 - Dual interplay
AU - Pampliega, Olatz
AU - Cuervo, Ana Maria
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Primary cilia are microtubule-based organelles for sensing of the extracellular milieu and transducing this information into the cell through a variety of molecular signaling pathways. Functioning of the primary cilium has been recently connected to autophagy, a pathway for degradation of cellular components in lysosomes. Autophagy regulates the length of the cilia by removing proteins required for ciliogenesis, a phenomenon that is molecularly different if performed by basal autophagy or when autophagy is induced in response to various stressors. Here we review the current knowledge about the dual interaction between autophagy and ciliogenesis, and discuss the potential role that deregulated ciliary autophagy could have in pathologies with alterations in autophagy and ciliogenesis.
AB - Primary cilia are microtubule-based organelles for sensing of the extracellular milieu and transducing this information into the cell through a variety of molecular signaling pathways. Functioning of the primary cilium has been recently connected to autophagy, a pathway for degradation of cellular components in lysosomes. Autophagy regulates the length of the cilia by removing proteins required for ciliogenesis, a phenomenon that is molecularly different if performed by basal autophagy or when autophagy is induced in response to various stressors. Here we review the current knowledge about the dual interaction between autophagy and ciliogenesis, and discuss the potential role that deregulated ciliary autophagy could have in pathologies with alterations in autophagy and ciliogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84955516959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955516959&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2016.01.008
DO - 10.1016/j.ceb.2016.01.008
M3 - Article
VL - 39
SP - 1
EP - 7
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
ER -