Autophagy and human disease

Emerging themes

Jaime L. Schneider, Ana Maria Cuervo

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume26
DOIs
StatePublished - 2014

Fingerprint

Autophagy
Recycling
Lysosomes
Dissection
Pathology

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Autophagy and human disease : Emerging themes. / Schneider, Jaime L.; Cuervo, Ana Maria.

In: Current Opinion in Genetics and Development, Vol. 26, 2014, p. 16-23.

Research output: Contribution to journalArticle

@article{500e52110150478a95f978abe6204332,
title = "Autophagy and human disease: Emerging themes",
abstract = "Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.",
author = "Schneider, {Jaime L.} and Cuervo, {Ana Maria}",
year = "2014",
doi = "10.1016/j.gde.2014.04.003",
language = "English (US)",
volume = "26",
pages = "16--23",
journal = "Current Opinion in Genetics and Development",
issn = "0959-437X",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Autophagy and human disease

T2 - Emerging themes

AU - Schneider, Jaime L.

AU - Cuervo, Ana Maria

PY - 2014

Y1 - 2014

N2 - Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.

AB - Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.

UR - http://www.scopus.com/inward/record.url?scp=84901833411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901833411&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2014.04.003

DO - 10.1016/j.gde.2014.04.003

M3 - Article

VL - 26

SP - 16

EP - 23

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

ER -