TY - JOUR
T1 - Autophagy and human disease
T2 - Emerging themes
AU - Schneider, Jaime L.
AU - Cuervo, Ana Maria
N1 - Funding Information:
Research in our group is supported by grants from the National Institutes of Health AG21904 , AG031782 , AG038072 ACTC, DK098408 and NS038370 , awards from The Rainwaters Foundation and The Beatrice and Roy Backus Foundation and a generous gift from Robert and Renee Belfer. JLS is supported by T32-GM007288 and F30AG046109 grants.
PY - 2014/6
Y1 - 2014/6
N2 - Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.
AB - Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.
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U2 - 10.1016/j.gde.2014.04.003
DO - 10.1016/j.gde.2014.04.003
M3 - Review article
C2 - 24907664
AN - SCOPUS:84901833411
SN - 0959-437X
VL - 26
SP - 16
EP - 23
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -