Autophagy and human disease: Emerging themes

Jaime L. Schneider, Ana Maria Cuervo

Research output: Contribution to journalReview article

180 Scopus citations

Abstract

Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Genetics and Development
Volume26
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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