Autophagy and disease: Always two sides to a problem

Research output: Contribution to journalReview article

182 Scopus citations

Abstract

Autophagy is a process traditionally known to contribute to cellular cleaning through the removal of intracellular components in lysosomes. In recent years, intensive scrutiny at the molecular level to which autophagy has been subjected has also contributed to expanding our understanding of the physiological role of this pathway. Added to the well-characterized role in quality control, autophagy has proved to be important in the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodelling, and cellular defence against extracellular insults and pathogens. It is not a surprise that, in light of this growing number of physiological functions, connections between autophagic malfunction and human pathologies have also been strengthened. In this review, we focus on several pathological conditions associated with primary or secondary defects in autophagy and comment on a recurring theme for many of them, ie the fact that autophagy can often exert both beneficial and aggravating effects on the progression of disease. Elucidating the factors that determine the switch between these dual functions of autophagy in disease has become a priority when considering the potential therapeutic implications of the pharmacological modulation of autophagy in many of these pathological conditions.

Original languageEnglish (US)
Pages (from-to)255-273
Number of pages19
JournalJournal of Pathology
Volume226
Issue number2
DOIs
StatePublished - Jan 1 2012

Keywords

  • T cell function
  • cancer
  • cardiomyopathy
  • immunity
  • lysosomes
  • neurodegeneration
  • protein aggregation
  • proteolysis
  • proteotoxicity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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