Autophagy and aging keeping organelles and the proteome healthy

Jaime L. Schneider, Ana Maria Cuervo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Maintenance of cellular homeostasis requires continuous surveillance of the intracellular environment. The combined action of the chaperone network and the proteolytic systems assures that altered proteins and organelles can be rapidly identified and eliminated from inside cells. Failure to perform this quality control leads to the accumulation of damaged products that become toxic for cells and often precipitate loss of cellular functionality and even cell death (Morimoto and Cuervo 2009). A gradual decline of the activity and efficiency of the cellular surveillance systems occurs with age and acts as an aggravating factor for different age-related pathologies such as neurodegenerative diseases and metabolic disorders (Morimoto 2008).

Original languageEnglish (US)
Title of host publicationMitochondrial Signaling in Health and Disease
PublisherCRC Press
Pages319-351
Number of pages33
ISBN (Electronic)9781439880036
ISBN (Print)9781439880029
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Schneider, J. L., & Cuervo, A. M. (2012). Autophagy and aging keeping organelles and the proteome healthy. In Mitochondrial Signaling in Health and Disease (pp. 319-351). CRC Press.