Autoantibodies to ribonucleoproteins

J. A. Hardin, T. Mimori

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Presently we recognize at least 12 different autoantibodies that involve ribonucleoproteins as antigens in patients with systemic lupus erythematosus (SLE) and other rheumatic diseases. Such autoantibodies have a number of clinically useful diagnostic associations. Moreover, they have proved to be powerful tools for understanding the structure and function of a variety of cellular components that involve RNA molecules. In SLE, autoantibodies that recognize the U1 snRNP (i.e. anti-(U1)RNP and anti-Sm antibodies) and the Ro scRNPs (i.e. anti-Ro and anti-La antibodies) are especially prominent in terms of their high frequency and titre. These particles, along with the nucleosome (which is the principal focus of autoantibodies to chromatin) appear to have active roles in eliciting autoimmune responses in such patients. Future studies aimed at understanding how and when these particular structures interact with the immune system could provide important insights into the aetiology and pathogenesis of this disorder.

Original languageEnglish (US)
Pages (from-to)485-505
Number of pages21
JournalClinics in Rheumatic Diseases
Volume11
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Ribonucleoproteins
Autoantibodies
Systemic Lupus Erythematosus
Anti-Idiotypic Antibodies
U1 Small Nuclear Ribonucleoproteins
Nucleosomes
Rheumatic Diseases
Autoimmunity
Chromatin
Immune System
RNA
Antigens

ASJC Scopus subject areas

  • Rheumatology

Cite this

Hardin, J. A., & Mimori, T. (1985). Autoantibodies to ribonucleoproteins. Clinics in Rheumatic Diseases, 11(3), 485-505.

Autoantibodies to ribonucleoproteins. / Hardin, J. A.; Mimori, T.

In: Clinics in Rheumatic Diseases, Vol. 11, No. 3, 1985, p. 485-505.

Research output: Contribution to journalArticle

Hardin, JA & Mimori, T 1985, 'Autoantibodies to ribonucleoproteins', Clinics in Rheumatic Diseases, vol. 11, no. 3, pp. 485-505.
Hardin JA, Mimori T. Autoantibodies to ribonucleoproteins. Clinics in Rheumatic Diseases. 1985;11(3):485-505.
Hardin, J. A. ; Mimori, T. / Autoantibodies to ribonucleoproteins. In: Clinics in Rheumatic Diseases. 1985 ; Vol. 11, No. 3. pp. 485-505.
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