Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch; Rudolf Kirchmair; Christian M. Kähler; Ruth Hogue-Angeletti; Reiner Fischer-Colbrie; Hans Winkler; Christian J. Wiedermann

doi:10.1016/0014-5793(93)81676-Q

Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch, Rudolf Kirchmair, Christian M. Kähler, Ruth Hogue-Angeletti, Reiner Fischer-Colbrie, Hans Winkler, Christian J. Wiedermann

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	FEBS Letters
Volume	334
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(93)81676-Q
State	Published - Nov 8 1993
Externally published	Yes

Keywords

Chemotaxis
Monocyte
Neurogenic inflammation
Secretogranin II
Secretoneurin

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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AU - Reinisch, Norbert

AU - Kirchmair, Rudolf

AU - Kähler, Christian M.

AU - Hogue-Angeletti, Ruth

AU - Fischer-Colbrie, Reiner

AU - Winkler, Hans

AU - Wiedermann, Christian J.

PY - 1993/11/8

Y1 - 1993/11/8

N2 - Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

AB - Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

KW - Chemotaxis

KW - Monocyte

KW - Neurogenic inflammation

KW - Secretogranin II

KW - Secretoneurin

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JF - FEBS Letters

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Attraction of human monocytes by the neuropeptide secretoneurin

Abstract

Keywords

ASJC Scopus subject areas

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