Abstract
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-44 |
| Number of pages | 4 |
| Journal | FEBS Letters |
| Volume | 334 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 8 1993 |
Keywords
- Chemotaxis
- Monocyte
- Neurogenic inflammation
- Secretogranin II
- Secretoneurin
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Cite this
Reinisch, N., Kirchmair, R., Kähler, C. M., Hogue-Angeletti, R., Fischer-Colbrie, R., Winkler, H., & Wiedermann, C. J. (1993). Attraction of human monocytes by the neuropeptide secretoneurin. FEBS Letters, 334(1), 41-44. https://doi.org/10.1016/0014-5793(93)81676-Q