TY - JOUR
T1 - Attraction of human monocytes by the neuropeptide secretoneurin
AU - Reinisch, Norbert
AU - Kirchmair, Rudolf
AU - Kähler, Christian M.
AU - Hogue-Angeletti, Ruth
AU - Fischer-Colbrie, Reiner
AU - Winkler, Hans
AU - Wiedermann, Christian J.
PY - 1993/11/8
Y1 - 1993/11/8
N2 - Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
AB - Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
KW - Chemotaxis
KW - Monocyte
KW - Neurogenic inflammation
KW - Secretogranin II
KW - Secretoneurin
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U2 - 10.1016/0014-5793(93)81676-Q
DO - 10.1016/0014-5793(93)81676-Q
M3 - Article
C2 - 8224224
AN - SCOPUS:0027383931
VL - 334
SP - 41
EP - 44
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -