Abstract
Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.
Original language | English (US) |
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Pages (from-to) | 41-44 |
Number of pages | 4 |
Journal | FEBS Letters |
Volume | 334 |
Issue number | 1 |
DOIs | |
State | Published - Nov 8 1993 |
Externally published | Yes |
Keywords
- Chemotaxis
- Monocyte
- Neurogenic inflammation
- Secretogranin II
- Secretoneurin
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology