Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch, Rudolf Kirchmair, Christian M. Kähler, Ruth Hogue-Angeletti, Reiner Fischer-Colbrie, Hans Winkler, Christian J. Wiedermann

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalFEBS Letters
Volume334
Issue number1
DOIs
StatePublished - Nov 8 1993

Keywords

  • Chemotaxis
  • Monocyte
  • Neurogenic inflammation
  • Secretogranin II
  • Secretoneurin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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