Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch; Rudolf Kirchmair; Christian M. Kähler; Ruth Hogue-Angeletti; Reiner Fischer-Colbrie; Hans Winkler; Christian J. Wiedermann

doi:10.1016/0014-5793(93)81676-Q

Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch, Rudolf Kirchmair, Christian M. Kähler, Ruth Hogue-Angeletti, Reiner Fischer-Colbrie, Hans Winkler, Christian J. Wiedermann

Developmental & Molecular Biology

Research output: Contribution to journal › Article

107 Scopus citations

Abstract

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	FEBS Letters
Volume	334
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(93)81676-Q
Publication status	Published - Nov 8 1993

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Keywords

Chemotaxis
Monocyte
Neurogenic inflammation
Secretogranin II
Secretoneurin

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

Cite this

Reinisch, N., Kirchmair, R., Kähler, C. M., Hogue-Angeletti, R., Fischer-Colbrie, R., Winkler, H., & Wiedermann, C. J. (1993). Attraction of human monocytes by the neuropeptide secretoneurin. FEBS Letters, 334(1), 41-44. https://doi.org/10.1016/0014-5793(93)81676-Q

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10.1016/0014-5793(93)81676-Q