Attraction of human monocytes by the neuropeptide secretoneurin

Norbert Reinisch, Rudolf Kirchmair, Christian M. Kähler, Ruth Hogue-Angeletti, Reiner Fischer-Colbrie, Hans Winkler, Christian J. Wiedermann

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalFEBS Letters
Volume334
Issue number1
DOIs
StatePublished - Nov 8 1993

Fingerprint

Neuropeptides
Monocytes
Secretogranin II
Unmyelinated Nerve Fibers
Substance P
Somatostatin
Amino Acids
Peptides
secretoneurin
Fibers

Keywords

  • Chemotaxis
  • Monocyte
  • Neurogenic inflammation
  • Secretogranin II
  • Secretoneurin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Reinisch, N., Kirchmair, R., Kähler, C. M., Hogue-Angeletti, R., Fischer-Colbrie, R., Winkler, H., & Wiedermann, C. J. (1993). Attraction of human monocytes by the neuropeptide secretoneurin. FEBS Letters, 334(1), 41-44. https://doi.org/10.1016/0014-5793(93)81676-Q

Attraction of human monocytes by the neuropeptide secretoneurin. / Reinisch, Norbert; Kirchmair, Rudolf; Kähler, Christian M.; Hogue-Angeletti, Ruth; Fischer-Colbrie, Reiner; Winkler, Hans; Wiedermann, Christian J.

In: FEBS Letters, Vol. 334, No. 1, 08.11.1993, p. 41-44.

Research output: Contribution to journalArticle

Reinisch, N, Kirchmair, R, Kähler, CM, Hogue-Angeletti, R, Fischer-Colbrie, R, Winkler, H & Wiedermann, CJ 1993, 'Attraction of human monocytes by the neuropeptide secretoneurin', FEBS Letters, vol. 334, no. 1, pp. 41-44. https://doi.org/10.1016/0014-5793(93)81676-Q
Reinisch N, Kirchmair R, Kähler CM, Hogue-Angeletti R, Fischer-Colbrie R, Winkler H et al. Attraction of human monocytes by the neuropeptide secretoneurin. FEBS Letters. 1993 Nov 8;334(1):41-44. https://doi.org/10.1016/0014-5793(93)81676-Q
Reinisch, Norbert ; Kirchmair, Rudolf ; Kähler, Christian M. ; Hogue-Angeletti, Ruth ; Fischer-Colbrie, Reiner ; Winkler, Hans ; Wiedermann, Christian J. / Attraction of human monocytes by the neuropeptide secretoneurin. In: FEBS Letters. 1993 ; Vol. 334, No. 1. pp. 41-44.
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