Attract: A method for identifying core pathways that define cellular phenotypes

Jessica C. Mar; Nicholas A. Matigian; John Quackenbush; Christine A. Wells

doi:10.1371/journal.pone.0025445

Attract: A method for identifying core pathways that define cellular phenotypes

Jessica C. Mar, Nicholas A. Matigian, John Quackenbush, Christine A. Wells

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been incorporated into the MeV software system.

Original language	English (US)
Article number	e25445
Journal	PloS one
Volume	6
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0025445
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General

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10.1371/journal.pone.0025445

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Attract: A method for identifying core pathways that define cellular phenotypes

Abstract

ASJC Scopus subject areas

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