Attract: A method for identifying core pathways that define cellular phenotypes

Jessica C. Mar, Nicholas A. Matigian, John Quackenbush, Christine A. Wells

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptome dataset. attract can be applied to a wide range of biological systems and is freely available as a Bioconductor package and has been incorporated into the MeV software system.

Original languageEnglish (US)
Article numbere25445
JournalPLoS One
Volume6
Issue number10
DOIs
StatePublished - 2011
Externally publishedYes

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Genes
Phenotype
phenotype
genes
Biological systems
Transcriptome
transcriptome
Software
methodology
cells
Datasets

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mar, J. C., Matigian, N. A., Quackenbush, J., & Wells, C. A. (2011). Attract: A method for identifying core pathways that define cellular phenotypes. PLoS One, 6(10), [e25445]. https://doi.org/10.1371/journal.pone.0025445

Attract : A method for identifying core pathways that define cellular phenotypes. / Mar, Jessica C.; Matigian, Nicholas A.; Quackenbush, John; Wells, Christine A.

In: PLoS One, Vol. 6, No. 10, e25445, 2011.

Research output: Contribution to journalArticle

Mar, Jessica C. ; Matigian, Nicholas A. ; Quackenbush, John ; Wells, Christine A. / Attract : A method for identifying core pathways that define cellular phenotypes. In: PLoS One. 2011 ; Vol. 6, No. 10.
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