TY - JOUR
T1 - Attained height, sex, and risk of cancer at different anatomic sites in the NIH-AARP Diet and Health Study
AU - Kabat, Geoffrey C.
AU - Kim, Mimi Y.
AU - Hollenbeck, Albert R.
AU - Rohan, Thomas E.
N1 - Funding Information:
Acknowledgments This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute (NCI). The present paper was supported by institutional funds from the Albert Einstein College of Medicine.
Publisher Copyright:
© 2014, Springer International Publishing Switzerland.
PY - 2014/11/18
Y1 - 2014/11/18
N2 - Purpose: To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women.Methods: The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the association of height with cancer risk.Conclusions: Different patterns were observed in the height–cancer association by sex. Studies investigating the biological mechanisms underlying the association of height with cancer risk should focus on those sites that show a reproducible association with attained height.Results: After adjustment for covariates, height was positively associated with increased risk of all cancers combined in both men [HR10 cm increase = 1.05 (95 % CI 1.04–1.06)] and women [HR10 cm increase = 1.08 (95 % CI 1.06–1.10)]. Several sites common to men and women showed significant positive associations with height: colon, rectum, kidney, melanoma, and non-Hodgkin’s lymphoma. For other shared sites, the association differed by sex. For still other sites, there was no clear association with height. Positive associations were also observed with cancers of the breast, endometrium, and prostate.
AB - Purpose: To examine the association of adult height with risk of cancer at different anatomic sites in a cohort of men and women.Methods: The association of self-reported height with subsequent cancer risk was assessed in 288,683 men and 192,514 women enrolled in the National Institutes of Health-AARP Diet and Health Study. After a median follow-up of 10.5 years, incident cancer was diagnosed in 51,139 men and 23,407 women. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the association of height with cancer risk.Conclusions: Different patterns were observed in the height–cancer association by sex. Studies investigating the biological mechanisms underlying the association of height with cancer risk should focus on those sites that show a reproducible association with attained height.Results: After adjustment for covariates, height was positively associated with increased risk of all cancers combined in both men [HR10 cm increase = 1.05 (95 % CI 1.04–1.06)] and women [HR10 cm increase = 1.08 (95 % CI 1.06–1.10)]. Several sites common to men and women showed significant positive associations with height: colon, rectum, kidney, melanoma, and non-Hodgkin’s lymphoma. For other shared sites, the association differed by sex. For still other sites, there was no clear association with height. Positive associations were also observed with cancers of the breast, endometrium, and prostate.
KW - Adult height
KW - Cancer sites
KW - Insulin-like growth factor-1
KW - Modifying factors
KW - Sex
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U2 - 10.1007/s10552-014-0476-1
DO - 10.1007/s10552-014-0476-1
M3 - Article
C2 - 25307804
AN - SCOPUS:84911807820
SN - 0957-5243
VL - 25
SP - 1697
EP - 1706
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -
