Atrophic cell processes of large motor neurons in the anterior horn in amyotrophic lateral sclerosis: Observation with silver impregnation method

Imaharu Nakano, Asao Hirano

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Investigation of silver-stained lumbar anterior horns in four autopsied cases of sporadic amyotrophic lateral sclerosis (ALS) revealed frequent extremely small cell processes originating from large motor neurons. Their perikarya were usually smaller in size than those of normal-looking ones and almost invariably had central chromatolysis-like changes, suggesting an intimate pathomorphological relationship between the perikarya and their processes. Although it was difficult to determine whether these small processes were atrophic dendrites or shrunken axons, some were recognized as dendrites from their multiple branchings and some were identified as axons from their tapering configuration followed by widening of the distal portion. Aggregates of lipofuscin were almost always present in the perikaryal portion from which an atrophic process arose. In addition, the somewhat argentophilic slender cytoplasm which in normal neurons separates lipofuscin from the cell surface and merges with the proximal part of a process, was prominently attenuated. The small processes were more frequently observed in cases with many spheroids and chromatolytic neurons. The change in the proximal portion of the processes may implicate some disturbance of functional connection between the soma and the cell processes in ALS.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalJournal of Neuropathology and Experimental Neurology
Volume46
Issue number1
StatePublished - 1987

Fingerprint

Amyotrophic Lateral Sclerosis
Motor Neurons
Horns
Silver
Lipofuscin
Observation
Dendrites
Axons
Neurons
Carisoprodol
Cytoplasm

Keywords

  • Amyotrophic lateral sclerosis
  • Bielschowsky
  • Modified
  • Neurons lower motor
  • Spinal cord lumbar
  • Stains and staining

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

@article{0b5eb7ad1c0c409f9f9cf21d335b34d7,
title = "Atrophic cell processes of large motor neurons in the anterior horn in amyotrophic lateral sclerosis: Observation with silver impregnation method",
abstract = "Investigation of silver-stained lumbar anterior horns in four autopsied cases of sporadic amyotrophic lateral sclerosis (ALS) revealed frequent extremely small cell processes originating from large motor neurons. Their perikarya were usually smaller in size than those of normal-looking ones and almost invariably had central chromatolysis-like changes, suggesting an intimate pathomorphological relationship between the perikarya and their processes. Although it was difficult to determine whether these small processes were atrophic dendrites or shrunken axons, some were recognized as dendrites from their multiple branchings and some were identified as axons from their tapering configuration followed by widening of the distal portion. Aggregates of lipofuscin were almost always present in the perikaryal portion from which an atrophic process arose. In addition, the somewhat argentophilic slender cytoplasm which in normal neurons separates lipofuscin from the cell surface and merges with the proximal part of a process, was prominently attenuated. The small processes were more frequently observed in cases with many spheroids and chromatolytic neurons. The change in the proximal portion of the processes may implicate some disturbance of functional connection between the soma and the cell processes in ALS.",
keywords = "Amyotrophic lateral sclerosis, Bielschowsky, Modified, Neurons lower motor, Spinal cord lumbar, Stains and staining",
author = "Imaharu Nakano and Asao Hirano",
year = "1987",
language = "English (US)",
volume = "46",
pages = "40--49",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Atrophic cell processes of large motor neurons in the anterior horn in amyotrophic lateral sclerosis

T2 - Observation with silver impregnation method

AU - Nakano, Imaharu

AU - Hirano, Asao

PY - 1987

Y1 - 1987

N2 - Investigation of silver-stained lumbar anterior horns in four autopsied cases of sporadic amyotrophic lateral sclerosis (ALS) revealed frequent extremely small cell processes originating from large motor neurons. Their perikarya were usually smaller in size than those of normal-looking ones and almost invariably had central chromatolysis-like changes, suggesting an intimate pathomorphological relationship between the perikarya and their processes. Although it was difficult to determine whether these small processes were atrophic dendrites or shrunken axons, some were recognized as dendrites from their multiple branchings and some were identified as axons from their tapering configuration followed by widening of the distal portion. Aggregates of lipofuscin were almost always present in the perikaryal portion from which an atrophic process arose. In addition, the somewhat argentophilic slender cytoplasm which in normal neurons separates lipofuscin from the cell surface and merges with the proximal part of a process, was prominently attenuated. The small processes were more frequently observed in cases with many spheroids and chromatolytic neurons. The change in the proximal portion of the processes may implicate some disturbance of functional connection between the soma and the cell processes in ALS.

AB - Investigation of silver-stained lumbar anterior horns in four autopsied cases of sporadic amyotrophic lateral sclerosis (ALS) revealed frequent extremely small cell processes originating from large motor neurons. Their perikarya were usually smaller in size than those of normal-looking ones and almost invariably had central chromatolysis-like changes, suggesting an intimate pathomorphological relationship between the perikarya and their processes. Although it was difficult to determine whether these small processes were atrophic dendrites or shrunken axons, some were recognized as dendrites from their multiple branchings and some were identified as axons from their tapering configuration followed by widening of the distal portion. Aggregates of lipofuscin were almost always present in the perikaryal portion from which an atrophic process arose. In addition, the somewhat argentophilic slender cytoplasm which in normal neurons separates lipofuscin from the cell surface and merges with the proximal part of a process, was prominently attenuated. The small processes were more frequently observed in cases with many spheroids and chromatolytic neurons. The change in the proximal portion of the processes may implicate some disturbance of functional connection between the soma and the cell processes in ALS.

KW - Amyotrophic lateral sclerosis

KW - Bielschowsky

KW - Modified

KW - Neurons lower motor

KW - Spinal cord lumbar

KW - Stains and staining

UR - http://www.scopus.com/inward/record.url?scp=0023070785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023070785&partnerID=8YFLogxK

M3 - Article

C2 - 2432193

AN - SCOPUS:0023070785

VL - 46

SP - 40

EP - 49

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 1

ER -