TY - JOUR
T1 - Atrial Fibrillation
T2 - JACC Council Perspectives
AU - ACC Electrophysiology Section Leadership Council
AU - Chung, Mina K.
AU - Refaat, Marwan
AU - Shen, Win Kuang
AU - Kutyifa, Valentina
AU - Cha, Yong Mei
AU - Di Biase, Luigi
AU - Baranchuk, Adrian
AU - Lampert, Rachel
AU - Natale, Andrea
AU - Fisher, John
AU - Lakkireddy, Dhanunjaya R.
N1 - Publisher Copyright:
© 2020
PY - 2020/4/14
Y1 - 2020/4/14
N2 - Atrial fibrillation (AF) is an increasingly prevalent arrhythmia; its pathophysiology and progression are well studied. Stroke and bleeding risk models have been created and validated. Decision tools for stroke prophylaxis are evolving, with better options at hand. Utilization of various diagnostic tools offer insight into AF burden and thromboembolic risk. Rate control, rhythm control, and stroke prophylaxis are the cornerstones of AF therapy. Although antiarrhythmic drugs are useful, AF ablation has become a primary therapeutic strategy. Pulmonary vein isolation is the cornerstone of AF ablation, and methods to improve ablation safety and efficacy continue to progress. Ablation of nonpulmonary vein sites is increasingly being recognized as an important strategy for treating nonparoxysmal AF. Several new ablation techniques and technologies and stroke prophylaxis are being explored. This is a contemporary review on the prevalence, pathophysiology, risk prediction, prophylaxis, treatment options, new insights for optimizing treatment outcomes, and emerging concepts of AF.
AB - Atrial fibrillation (AF) is an increasingly prevalent arrhythmia; its pathophysiology and progression are well studied. Stroke and bleeding risk models have been created and validated. Decision tools for stroke prophylaxis are evolving, with better options at hand. Utilization of various diagnostic tools offer insight into AF burden and thromboembolic risk. Rate control, rhythm control, and stroke prophylaxis are the cornerstones of AF therapy. Although antiarrhythmic drugs are useful, AF ablation has become a primary therapeutic strategy. Pulmonary vein isolation is the cornerstone of AF ablation, and methods to improve ablation safety and efficacy continue to progress. Ablation of nonpulmonary vein sites is increasingly being recognized as an important strategy for treating nonparoxysmal AF. Several new ablation techniques and technologies and stroke prophylaxis are being explored. This is a contemporary review on the prevalence, pathophysiology, risk prediction, prophylaxis, treatment options, new insights for optimizing treatment outcomes, and emerging concepts of AF.
KW - atrial fibrillation
KW - future
KW - present
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U2 - 10.1016/j.jacc.2020.02.025
DO - 10.1016/j.jacc.2020.02.025
M3 - Review article
C2 - 32273035
AN - SCOPUS:85082558264
SN - 0735-1097
VL - 75
SP - 1689
EP - 1713
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 14
ER -