Atrial fibrillation and microRNAs

Gaetano Santulli; Guido Iaccarino; Nicola De Luca; Bruno Trimarco; Gianluigi Condorelli

doi:10.3389/fphys.2014.00015

Atrial fibrillation and microRNAs

Gaetano Santulli, Guido Iaccarino, Nicola De Luca, Bruno Trimarco, Gianluigi Condorelli

Research output: Contribution to journal › Short survey › peer-review

117 Scopus citations

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

Original language	English (US)
Article number	00015
Journal	Frontiers in Physiology
Volume	5 JAN
DOIs	https://doi.org/10.3389/fphys.2014.00015
State	Published - 2014
Externally published	Yes

Keywords

Apoptosis
Atrial fibrillation
Electrical remodeling
Electrophysiology
Fibrosis
MicroRNA (miRNA)
Structural remodeling

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.3389/fphys.2014.00015

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title = "Atrial fibrillation and microRNAs",

abstract = "Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.",

keywords = "Apoptosis, Atrial fibrillation, Electrical remodeling, Electrophysiology, Fibrosis, MicroRNA (miRNA), Structural remodeling",

author = "Gaetano Santulli and Guido Iaccarino and {De Luca}, Nicola and Bruno Trimarco and Gianluigi Condorelli",

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T1 - Atrial fibrillation and microRNAs

AU - Santulli, Gaetano

AU - Iaccarino, Guido

AU - De Luca, Nicola

AU - Trimarco, Bruno

AU - Condorelli, Gianluigi

PY - 2014

Y1 - 2014

N2 - Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

AB - Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

KW - Apoptosis

KW - Atrial fibrillation

KW - Electrical remodeling

KW - Electrophysiology

KW - Fibrosis

KW - MicroRNA (miRNA)

KW - Structural remodeling

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DO - 10.3389/fphys.2014.00015

M3 - Short survey

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VL - 5 JAN

JO - Frontiers in Physiology

JF - Frontiers in Physiology

M1 - 00015

ER -

Atrial fibrillation and microRNAs

Abstract

Keywords

ASJC Scopus subject areas

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