Atrial fibrillation and microRNAs

Gaetano Santulli, Guido Iaccarino, Nicola De Luca, Bruno Trimarco, Gianluigi Condorelli

Research output: Contribution to journalShort survey

77 Scopus citations

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.

Original languageEnglish (US)
Article number00015
JournalFrontiers in Physiology
Volume5 JAN
DOIs
StatePublished - Feb 11 2014
Externally publishedYes

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Keywords

  • Apoptosis
  • Atrial fibrillation
  • Electrical remodeling
  • Electrophysiology
  • Fibrosis
  • MicroRNA (miRNA)
  • Structural remodeling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Santulli, G., Iaccarino, G., De Luca, N., Trimarco, B., & Condorelli, G. (2014). Atrial fibrillation and microRNAs. Frontiers in Physiology, 5 JAN, [00015]. https://doi.org/10.3389/fphys.2014.00015