Atrial fibrillation ablation without interruption of anticoagulation

Andrea Natale, Pasquale Santangeli, Luigi Di Biase, Javier E. Sanchez, Rodney Horton

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Atrial fibrillation (AF) can be cured by pulmonary vein antrum isolation (PVAI) in a substantial proportion of patients. The high efficacy of PVAI is partially undermined by a small but concrete periprocedural risk of complications, such as thromboembolic events and bleeding. A correct management of anticoagulation is essential to prevent such complications. Performing PVAI without interruption of oral anticoagulation has been demonstrated feasible by our group in previous studies. Recently, we reported that continuation of therapeutic warfarin during radiofrequency catheter ablation consistently reduces the risk of periprocedural stroke/transient ischemic attack without increasing the risk of hemorrhagic events. Of note, interrupting warfarin anticoagulation may actually increase the risk of stroke even when bridged with heparin. The latter strategy is also associated with an increased risk of minor bleeding. With regard to major bleeding, we found no significant difference between patients with a therapeutic INR and those who were bridged with heparin. Therefore, continuation of therapeutic warfarin during ablation of AF appears to be the best anticoagulation strategy. In this paper we summarize our experience with AF ablation without interruption of anticoagulation.

Original languageEnglish (US)
Article number837841
JournalCardiology Research and Practice
Volume1
Issue number1
DOIs
StatePublished - 2011
Externally publishedYes

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Atrial Fibrillation
Pulmonary Veins
Warfarin
Hemorrhage
Heparin
Stroke
International Normalized Ratio
Catheter Ablation
Transient Ischemic Attack
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Atrial fibrillation ablation without interruption of anticoagulation. / Natale, Andrea; Santangeli, Pasquale; Di Biase, Luigi; Sanchez, Javier E.; Horton, Rodney.

In: Cardiology Research and Practice, Vol. 1, No. 1, 837841, 2011.

Research output: Contribution to journalArticle

Natale, Andrea ; Santangeli, Pasquale ; Di Biase, Luigi ; Sanchez, Javier E. ; Horton, Rodney. / Atrial fibrillation ablation without interruption of anticoagulation. In: Cardiology Research and Practice. 2011 ; Vol. 1, No. 1.
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