Atopic Disease and Herpes Simplex Eye Disease

A Population-Based Case-Control Study

Tisha Prabriputaloong, Todd P. Margolis, Thomas M. Lietman, Ira G. Wong, Rookaya Mather, David C. Gritz

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34%, 58/172) than the clinic-based (25%, 43/172) or the population-based controls (21%, 36/172, odds ratio (OR) 1.5, 95% confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95%, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13% (22/172) of patients with HSV ocular disease as compared with 6% (11/172) of patients in the clinic control group and 3% (5/172) of patients in the population control group (OR 2.0, 95% CI 0.7 to 5.9 and OR 4.8, 95% CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls.

Original languageEnglish (US)
JournalAmerican Journal of Ophthalmology
Volume142
Issue number5
DOIs
StatePublished - Nov 2006
Externally publishedYes

Fingerprint

Herpes Simplex
Eye Diseases
Simplexvirus
Virus Diseases
Case-Control Studies
Population
Odds Ratio
Confidence Intervals
Population Control
Control Groups
Health Maintenance Organizations
Population Groups
Medical Records
Hospital Emergency Service
Adrenal Cortex Hormones
Hospitalization
Research Design
Observation
Outcome Assessment (Health Care)
Databases

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Prabriputaloong, T., Margolis, T. P., Lietman, T. M., Wong, I. G., Mather, R., & Gritz, D. C. (2006). Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study. American Journal of Ophthalmology, 142(5). https://doi.org/10.1016/j.ajo.2006.06.050

Atopic Disease and Herpes Simplex Eye Disease : A Population-Based Case-Control Study. / Prabriputaloong, Tisha; Margolis, Todd P.; Lietman, Thomas M.; Wong, Ira G.; Mather, Rookaya; Gritz, David C.

In: American Journal of Ophthalmology, Vol. 142, No. 5, 11.2006.

Research output: Contribution to journalArticle

Prabriputaloong, T, Margolis, TP, Lietman, TM, Wong, IG, Mather, R & Gritz, DC 2006, 'Atopic Disease and Herpes Simplex Eye Disease: A Population-Based Case-Control Study', American Journal of Ophthalmology, vol. 142, no. 5. https://doi.org/10.1016/j.ajo.2006.06.050
Prabriputaloong, Tisha ; Margolis, Todd P. ; Lietman, Thomas M. ; Wong, Ira G. ; Mather, Rookaya ; Gritz, David C. / Atopic Disease and Herpes Simplex Eye Disease : A Population-Based Case-Control Study. In: American Journal of Ophthalmology. 2006 ; Vol. 142, No. 5.
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abstract = "Purpose: To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease. Design: Retrospective, population-based, case-control study. Methods: setting: Large, regional health maintenance organization (Northern California Kaiser Permanente). study Population: 1,042,351 people over a one-year period. observation Procedures: Electronic database search for HSV ocular disease and subsequent chart review determined study eligibility. Two age-matched control groups (one population-based and one clinic-based) were randomly chosen. Medical record review determined the presence of atopy. Severe atopic disease was defined by diagnostic code or illness requiring an emergency room visit, hospitalization, or treatment with a systemic corticosteroid. main Outcome Measures: Presence of HSV eye disease, presence of atopy, and characterization of atopy severity. Results: HSV eye disease was found in 172 patients. HSV cases had a greater prevalence of atopy (34{\%}, 58/172) than the clinic-based (25{\%}, 43/172) or the population-based controls (21{\%}, 36/172, odds ratio (OR) 1.5, 95{\%} confidence interval (CI) 0.9 to 2.6 and OR 1.9, 95{\%}, CI 1.1 to 3.3, respectively). The association of HSV ocular disease with severe atopy was even greater, with a history of severe atopic disease in 13{\%} (22/172) of patients with HSV ocular disease as compared with 6{\%} (11/172) of patients in the clinic control group and 3{\%} (5/172) of patients in the population control group (OR 2.0, 95{\%} CI 0.7 to 5.9 and OR 4.8, 95{\%} CI 1.6 to 19.2, respectively). Conclusions: Patients with HSV ocular disease are more likely to have a history of atopic disease, especially severe atopic disease, than age-matched controls.",
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