TY - JOUR
T1 - Atopic dermatitis results in intrinsic barrier and immune abnormalities
T2 - Implications for contact dermatitis
AU - Gittler, Julia K.
AU - Krueger, James G.
AU - Guttman-Yassky, Emma
PY - 2013/2
Y1 - 2013/2
N2 - Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.
AB - Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), are common skin diseases. These diseases are characterized by skin inflammation mediated by activated innate immunity or acquired immune mechanisms. Although AD, ICD, and ACD can be encountered in pure forms by allergists and dermatologists, patients with AD often present with increased frequency of ICD and ACD. Although a disturbed barrier alone could potentiate immune reactivity in patients with AD through increased antigen penetration, additional immune mechanisms might explain the increased susceptibility of atopic patients to ICD and ACD. This review discusses cellular pathways associated with increased skin inflammation in all 3 conditions and presents mechanisms that might contribute to the increased rate of ICD and ACD in patients with AD.
KW - Atopic dermatitis
KW - T17
KW - T2
KW - allergic contact dermatitis
KW - contact hypersensitivity
KW - epidermal barrier
KW - immune activation
KW - irritant contact dermatitis
UR - http://www.scopus.com/inward/record.url?scp=84873411006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873411006&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2012.06.048
DO - 10.1016/j.jaci.2012.06.048
M3 - Article
C2 - 22939651
AN - SCOPUS:84873411006
SN - 0091-6749
VL - 131
SP - 300
EP - 313
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -