Atomic displacement parameters of homologous proteins

Conservation of dynamics

V. M S Lenin, S. Parthasarathy, M. R N Murthy

Research output: Contribution to journalArticle

Abstract

Atomic displacement parameters (ADPs) obtained from high-resolution refinement of protein structures represent the mean square displacement of protein atoms from their centroid positions. They contain information regarding the flexibility of the polypeptide. Comparative analysis of the ADPs in homologous proteins shows that the local flexibility of the polypeptide is not correlated to the mutability of the segment. The flexible and rigid regions in the three-dimensional fold of proteins remain largely conserved during the course of evolution. In related proteins, the variation in the flexibility of a given segment is only weakly correlated to the variation of the amino acid sequence at the corresponding positions. These results illustrate that the relationship between sequence and dynamics has degeneracy similar to that of sequence and three-dimensional structure. The observations are consistent with the importance of protein flexibility to protein function.

Original languageEnglish (US)
Pages (from-to)1098-1105
Number of pages8
JournalCurrent Science
Volume78
Issue number9
StatePublished - May 10 2000
Externally publishedYes

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Proteins
proteins
polypeptides
Peptides
protein structure
amino acid sequences
Amino Acid Sequence

ASJC Scopus subject areas

  • General
  • Agricultural and Biological Sciences(all)

Cite this

Lenin, V. M. S., Parthasarathy, S., & Murthy, M. R. N. (2000). Atomic displacement parameters of homologous proteins: Conservation of dynamics. Current Science, 78(9), 1098-1105.

Atomic displacement parameters of homologous proteins : Conservation of dynamics. / Lenin, V. M S; Parthasarathy, S.; Murthy, M. R N.

In: Current Science, Vol. 78, No. 9, 10.05.2000, p. 1098-1105.

Research output: Contribution to journalArticle

Lenin, VMS, Parthasarathy, S & Murthy, MRN 2000, 'Atomic displacement parameters of homologous proteins: Conservation of dynamics', Current Science, vol. 78, no. 9, pp. 1098-1105.
Lenin VMS, Parthasarathy S, Murthy MRN. Atomic displacement parameters of homologous proteins: Conservation of dynamics. Current Science. 2000 May 10;78(9):1098-1105.
Lenin, V. M S ; Parthasarathy, S. ; Murthy, M. R N. / Atomic displacement parameters of homologous proteins : Conservation of dynamics. In: Current Science. 2000 ; Vol. 78, No. 9. pp. 1098-1105.
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