Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.

Susie N. Hong, Philimon Gona, Joao Daniel T. Fontes, Noriko Oyama, Raymond H. Chan, Satish Kenchaiah, Connie W. Tsao, Susan B. Yeon, Renate B. Schnabel, John F. Keaney, Christopher J. O'Donnell, Emelia J. Benjamin, Warren J. Manning

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort. We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09). In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.

Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume2
Issue number6
StatePublished - 2013
Externally publishedYes

Fingerprint

Atherosclerosis
Biomarkers
Magnetic Resonance Imaging
1-Alkyl-2-acetylglycerophosphocholine Esterase
Receptors, Tumor Necrosis Factor, Type II
Interleukin-18
P-Selectin
Chemokine CCL2
Intercellular Adhesion Molecule-1
C-Reactive Protein
Fibrinogen
Interleukin-6
Cohort Studies
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. / Hong, Susie N.; Gona, Philimon; Fontes, Joao Daniel T.; Oyama, Noriko; Chan, Raymond H.; Kenchaiah, Satish; Tsao, Connie W.; Yeon, Susan B.; Schnabel, Renate B.; Keaney, John F.; O'Donnell, Christopher J.; Benjamin, Emelia J.; Manning, Warren J.

In: Journal of the American Heart Association, Vol. 2, No. 6, 2013.

Research output: Contribution to journalArticle

Hong, SN, Gona, P, Fontes, JDT, Oyama, N, Chan, RH, Kenchaiah, S, Tsao, CW, Yeon, SB, Schnabel, RB, Keaney, JF, O'Donnell, CJ, Benjamin, EJ & Manning, WJ 2013, 'Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.', Journal of the American Heart Association, vol. 2, no. 6.
Hong, Susie N. ; Gona, Philimon ; Fontes, Joao Daniel T. ; Oyama, Noriko ; Chan, Raymond H. ; Kenchaiah, Satish ; Tsao, Connie W. ; Yeon, Susan B. ; Schnabel, Renate B. ; Keaney, John F. ; O'Donnell, Christopher J. ; Benjamin, Emelia J. ; Manning, Warren J. / Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study. In: Journal of the American Heart Association. 2013 ; Vol. 2, No. 6.
@article{2d7d95f2e94d48c39713961aa02b567c,
title = "Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.",
abstract = "The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort. We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09). In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.",
author = "Hong, {Susie N.} and Philimon Gona and Fontes, {Joao Daniel T.} and Noriko Oyama and Chan, {Raymond H.} and Satish Kenchaiah and Tsao, {Connie W.} and Yeon, {Susan B.} and Schnabel, {Renate B.} and Keaney, {John F.} and O'Donnell, {Christopher J.} and Benjamin, {Emelia J.} and Manning, {Warren J.}",
year = "2013",
language = "English (US)",
volume = "2",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study.

AU - Hong, Susie N.

AU - Gona, Philimon

AU - Fontes, Joao Daniel T.

AU - Oyama, Noriko

AU - Chan, Raymond H.

AU - Kenchaiah, Satish

AU - Tsao, Connie W.

AU - Yeon, Susan B.

AU - Schnabel, Renate B.

AU - Keaney, John F.

AU - O'Donnell, Christopher J.

AU - Benjamin, Emelia J.

AU - Manning, Warren J.

PY - 2013

Y1 - 2013

N2 - The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort. We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09). In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.

AB - The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort. We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09). In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.

UR - http://www.scopus.com/inward/record.url?scp=84902290930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902290930&partnerID=8YFLogxK

M3 - Article

C2 - 24242683

AN - SCOPUS:84902290930

VL - 2

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 6

ER -