Atherosclerosis in Survivors of Kawasaki Disease

Monesha Gupta-Malhotra, Dorota Gruber, Seena S. Abraham, Mary J. Roman, John B. Zabriskie, Lisa C. Hudgins, Patrick A. Flynn, Daniel M. Levine, Uzoma Okorie, Aline Baday, Myles S. Schiller, Janet Maturi, Diane Meehan, Joshua Dyme, Thomas S. Parker, Knut M. Wittkowski, Welton M. Gersony, Rubin S. Cooper

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objectives: To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects. Study design: Twenty-eight patients with KD (7-20 years after acute illness) and 27 age-matched healthy control subjects were examined for medical and dietary history, serum markers of atherosclerotic risk and inflammation, carotid intimal-medial thickness (CIMT) with vascular ultrasound scanning and arterial stiffness with applanation tonometry. Results: Patients and control subjects were similar in age, sex, body mass index, waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet, high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteine level, glucose level, insulin level, CIMT, arterial stiffness, C-reactive protein level, and inflammatory cytokine level. Levels of total cholesterol and apolipoprotein B were significantly higher in patients with KD than in control subjects. Conclusions: There was no evidence of increased atherosclerosis. Small but significant differences in cholesterol and apolipoprotein B levels could suggest increased future risk for atherosclerosis and warrant further study.

Original languageEnglish (US)
Pages (from-to)572-577
Number of pages6
JournalJournal of Pediatrics
Volume155
Issue number4
DOIs
Publication statusPublished - Oct 1 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Gupta-Malhotra, M., Gruber, D., Abraham, S. S., Roman, M. J., Zabriskie, J. B., Hudgins, L. C., ... Cooper, R. S. (2009). Atherosclerosis in Survivors of Kawasaki Disease. Journal of Pediatrics, 155(4), 572-577. https://doi.org/10.1016/j.jpeds.2009.04.054