Atherosclerosis in Survivors of Kawasaki Disease

Monesha Gupta-Malhotra, Dorota Gruber, Seena S. Abraham, Mary J. Roman, John B. Zabriskie, Lisa C. Hudgins, Patrick A. Flynn, Daniel M. Levine, Uzoma Okorie, Aline Baday, Myles S. Schiller, Janet Maturi, Diane Meehan, Joshua Dyme, Thomas S. Parker, Knut M. Wittkowski, Welton M. Gersony, Rubin S. Cooper

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objectives: To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects. Study design: Twenty-eight patients with KD (7-20 years after acute illness) and 27 age-matched healthy control subjects were examined for medical and dietary history, serum markers of atherosclerotic risk and inflammation, carotid intimal-medial thickness (CIMT) with vascular ultrasound scanning and arterial stiffness with applanation tonometry. Results: Patients and control subjects were similar in age, sex, body mass index, waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet, high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteine level, glucose level, insulin level, CIMT, arterial stiffness, C-reactive protein level, and inflammatory cytokine level. Levels of total cholesterol and apolipoprotein B were significantly higher in patients with KD than in control subjects. Conclusions: There was no evidence of increased atherosclerosis. Small but significant differences in cholesterol and apolipoprotein B levels could suggest increased future risk for atherosclerosis and warrant further study.

Original languageEnglish (US)
Pages (from-to)572-577
Number of pages6
JournalJournal of Pediatrics
Volume155
Issue number4
DOIs
StatePublished - Oct 2009
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
Survivors
Atherosclerosis
Tunica Intima
Vascular Stiffness
Apolipoproteins B
Blood Vessels
Healthy Volunteers
Cholesterol
Inflammation
Lipoprotein(a)
Waist-Hip Ratio
Manometry
Homocysteine
C-Reactive Protein
HDL Cholesterol
Body Mass Index
Biomarkers
Smoking
Insulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gupta-Malhotra, M., Gruber, D., Abraham, S. S., Roman, M. J., Zabriskie, J. B., Hudgins, L. C., ... Cooper, R. S. (2009). Atherosclerosis in Survivors of Kawasaki Disease. Journal of Pediatrics, 155(4), 572-577. https://doi.org/10.1016/j.jpeds.2009.04.054

Atherosclerosis in Survivors of Kawasaki Disease. / Gupta-Malhotra, Monesha; Gruber, Dorota; Abraham, Seena S.; Roman, Mary J.; Zabriskie, John B.; Hudgins, Lisa C.; Flynn, Patrick A.; Levine, Daniel M.; Okorie, Uzoma; Baday, Aline; Schiller, Myles S.; Maturi, Janet; Meehan, Diane; Dyme, Joshua; Parker, Thomas S.; Wittkowski, Knut M.; Gersony, Welton M.; Cooper, Rubin S.

In: Journal of Pediatrics, Vol. 155, No. 4, 10.2009, p. 572-577.

Research output: Contribution to journalArticle

Gupta-Malhotra, M, Gruber, D, Abraham, SS, Roman, MJ, Zabriskie, JB, Hudgins, LC, Flynn, PA, Levine, DM, Okorie, U, Baday, A, Schiller, MS, Maturi, J, Meehan, D, Dyme, J, Parker, TS, Wittkowski, KM, Gersony, WM & Cooper, RS 2009, 'Atherosclerosis in Survivors of Kawasaki Disease', Journal of Pediatrics, vol. 155, no. 4, pp. 572-577. https://doi.org/10.1016/j.jpeds.2009.04.054
Gupta-Malhotra M, Gruber D, Abraham SS, Roman MJ, Zabriskie JB, Hudgins LC et al. Atherosclerosis in Survivors of Kawasaki Disease. Journal of Pediatrics. 2009 Oct;155(4):572-577. https://doi.org/10.1016/j.jpeds.2009.04.054
Gupta-Malhotra, Monesha ; Gruber, Dorota ; Abraham, Seena S. ; Roman, Mary J. ; Zabriskie, John B. ; Hudgins, Lisa C. ; Flynn, Patrick A. ; Levine, Daniel M. ; Okorie, Uzoma ; Baday, Aline ; Schiller, Myles S. ; Maturi, Janet ; Meehan, Diane ; Dyme, Joshua ; Parker, Thomas S. ; Wittkowski, Knut M. ; Gersony, Welton M. ; Cooper, Rubin S. / Atherosclerosis in Survivors of Kawasaki Disease. In: Journal of Pediatrics. 2009 ; Vol. 155, No. 4. pp. 572-577.
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AU - Zabriskie, John B.

AU - Hudgins, Lisa C.

AU - Flynn, Patrick A.

AU - Levine, Daniel M.

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AU - Schiller, Myles S.

AU - Maturi, Janet

AU - Meehan, Diane

AU - Dyme, Joshua

AU - Parker, Thomas S.

AU - Wittkowski, Knut M.

AU - Gersony, Welton M.

AU - Cooper, Rubin S.

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