TY - JOUR
T1 - Associations of sleep-disordered breathing and insomnia with incident hypertension and diabetes
T2 - The hispanic community health study/study of latinos
AU - Li, Xiaoyu
AU - Sotres-Alvarez, Daniela
AU - Gallo, Linda C.
AU - Ramos, Alberto R.
AU - Aviles-Santa, Larissa
AU - Perreira, Krista M.
AU - Isasi, Carmen R.
AU - Zee, Phyllis C.
AU - Savin, Kimberly L.
AU - Schneiderman, Neil
AU - Wassertheil-Smoller, Sylvia
AU - Sofer, Tamar
AU - Daviglus, Martha
AU - Redline, Susan
N1 - Publisher Copyright:
Copyright © 2021 by the American Thoracic Society.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Rationale: Sleep disorders are associated with hypertension and diabetes, which are primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanic/Latino individuals, in whom cardiovascular death is the leading cause of mortality. Objectives: To investigate the prospective associations of sleep-disordered breathing (SDB) and insomnia with incident hypertension and diabetes among U.S. Hispanic/Latino people over 6 years of follow-up and to assess potential sex differences in these associations. Methods: Data from 11,623 Hispanic/Latino participants in the Hispanic Community Health Study/Study of Latinos (visit 1, 2008–2011; visit 2, 2014–2017) were analyzed using survey logistic regression models, adjusting for potential confounders. Measurements and Main Results: SDB (apnea–hypopnea index of 5 or more) and insomnia (Women’s Health Initiative Insomnia Rating Scale of 9 or more) were measured at baseline. Incident hypertension (stage 2 or greater) and diabetes were defined according to national guidelines. In the target population, 52.6% were women, with a mean age of 41.1 6 14.9 years at baseline. SDB was associated with 1.54 higher adjusted odds of incident hypertension (95% confidence interval [CI], 1.18–2.00) and 1.33 higher odds of incident diabetes (95% CI, 1.05–1.67) compared with no SDB. Insomnia was associated with incident hypertension (odds ratio, 1.37; 95% CI, 1.11–1.69) but not with diabetes. The association between insomnia and incident hypertension was stronger among men than among women. Conclusions: SDB was associated with incident hypertension and diabetes. Insomnia was associated with incident hypertension. These findings support the importance of sleep disorders as modifiable targets for disease prevention and reduction.
AB - Rationale: Sleep disorders are associated with hypertension and diabetes, which are primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanic/Latino individuals, in whom cardiovascular death is the leading cause of mortality. Objectives: To investigate the prospective associations of sleep-disordered breathing (SDB) and insomnia with incident hypertension and diabetes among U.S. Hispanic/Latino people over 6 years of follow-up and to assess potential sex differences in these associations. Methods: Data from 11,623 Hispanic/Latino participants in the Hispanic Community Health Study/Study of Latinos (visit 1, 2008–2011; visit 2, 2014–2017) were analyzed using survey logistic regression models, adjusting for potential confounders. Measurements and Main Results: SDB (apnea–hypopnea index of 5 or more) and insomnia (Women’s Health Initiative Insomnia Rating Scale of 9 or more) were measured at baseline. Incident hypertension (stage 2 or greater) and diabetes were defined according to national guidelines. In the target population, 52.6% were women, with a mean age of 41.1 6 14.9 years at baseline. SDB was associated with 1.54 higher adjusted odds of incident hypertension (95% confidence interval [CI], 1.18–2.00) and 1.33 higher odds of incident diabetes (95% CI, 1.05–1.67) compared with no SDB. Insomnia was associated with incident hypertension (odds ratio, 1.37; 95% CI, 1.11–1.69) but not with diabetes. The association between insomnia and incident hypertension was stronger among men than among women. Conclusions: SDB was associated with incident hypertension and diabetes. Insomnia was associated with incident hypertension. These findings support the importance of sleep disorders as modifiable targets for disease prevention and reduction.
KW - Diabetes
KW - Hispanic/Latino
KW - Hypertension
KW - Insomnia
KW - Sleep-disordered breathing
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U2 - 10.1164/rccm.201912-2330OC
DO - 10.1164/rccm.201912-2330OC
M3 - Article
C2 - 32758008
AN - SCOPUS:85100491938
SN - 1073-449X
VL - 203
SP - 356
EP - 365
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 3
ER -