Associations of obesity and asthma with functional exercise capacity in urban minority adolescents

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. Methods One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 normal-weight non-asthmatics underwent anthropometric measures, 6-minute walk test (6MWT) as measure of functional exercise capacity and spirometry as measure of pulmonary function. The 6-minute walk distance (6MWD) was compared between the four study groups. The association of 6MWD with measures of lower airway obstruction, and measures of adiposity was assessed. Results The 6MWD was lower among the obese groups with the least distance covered by the obese asthmatic group (P = 0.02). In the obese asthmatic group, there was a negative correlation between 6MWD and body mass index (BMI) (r = -0.35, P = 0.03), but no association was noted with percent-predicted forced expiratory volume in the 1st second (FEV1; r = 0.07, P = 0.70). Conversely, the 6MWD correlated with FEV1 among normal-weight asthmatics (r = 0.45, P = 0.04) and normal-weight non-asthmatics (r = 0.4, P = 0.03), but was not associated with BMI in either of the two groups. After adjusting for age, height, gender, and ethnicity, BMI was noted to be a significant predictor (β -2.76, 95% CI -4.77 to -0.76, P < 0.01) of the 6MWD among the obese while percent predicted FEV1 (β 1.87, 95% CI 0.28-3.45, P = 0.02) was a significant predictor among the normal-weight participants. Conclusions Our findings suggest that among urban minority obese asthmatic adolescents, functional exercise capacity was associated with obesity, rather than pulmonary function. Pediatr Pulmonol. 2012. 47:1061-1069.

Original languageEnglish (US)
Pages (from-to)1061-1069
Number of pages9
JournalPediatric Pulmonology
Volume47
Issue number11
DOIs
StatePublished - Oct 2012

Fingerprint

Asthma
Obesity
Exercise
Weights and Measures
Body Mass Index
Lung
Spirometry
Adiposity
Forced Expiratory Volume
Airway Obstruction
Hispanic Americans
African Americans

Keywords

  • adolescents
  • asthma
  • functional exercise capacity
  • obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Associations of obesity and asthma with functional exercise capacity in urban minority adolescents. / Rastogi, Deepa; Khan, Unab I.; Isasi, Carmen R.; Coupey, Susan M.

In: Pediatric Pulmonology, Vol. 47, No. 11, 10.2012, p. 1061-1069.

Research output: Contribution to journalArticle

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N2 - Purpose To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. Methods One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 normal-weight non-asthmatics underwent anthropometric measures, 6-minute walk test (6MWT) as measure of functional exercise capacity and spirometry as measure of pulmonary function. The 6-minute walk distance (6MWD) was compared between the four study groups. The association of 6MWD with measures of lower airway obstruction, and measures of adiposity was assessed. Results The 6MWD was lower among the obese groups with the least distance covered by the obese asthmatic group (P = 0.02). In the obese asthmatic group, there was a negative correlation between 6MWD and body mass index (BMI) (r = -0.35, P = 0.03), but no association was noted with percent-predicted forced expiratory volume in the 1st second (FEV1; r = 0.07, P = 0.70). Conversely, the 6MWD correlated with FEV1 among normal-weight asthmatics (r = 0.45, P = 0.04) and normal-weight non-asthmatics (r = 0.4, P = 0.03), but was not associated with BMI in either of the two groups. After adjusting for age, height, gender, and ethnicity, BMI was noted to be a significant predictor (β -2.76, 95% CI -4.77 to -0.76, P < 0.01) of the 6MWD among the obese while percent predicted FEV1 (β 1.87, 95% CI 0.28-3.45, P = 0.02) was a significant predictor among the normal-weight participants. Conclusions Our findings suggest that among urban minority obese asthmatic adolescents, functional exercise capacity was associated with obesity, rather than pulmonary function. Pediatr Pulmonol. 2012. 47:1061-1069.

AB - Purpose To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. Methods One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 normal-weight non-asthmatics underwent anthropometric measures, 6-minute walk test (6MWT) as measure of functional exercise capacity and spirometry as measure of pulmonary function. The 6-minute walk distance (6MWD) was compared between the four study groups. The association of 6MWD with measures of lower airway obstruction, and measures of adiposity was assessed. Results The 6MWD was lower among the obese groups with the least distance covered by the obese asthmatic group (P = 0.02). In the obese asthmatic group, there was a negative correlation between 6MWD and body mass index (BMI) (r = -0.35, P = 0.03), but no association was noted with percent-predicted forced expiratory volume in the 1st second (FEV1; r = 0.07, P = 0.70). Conversely, the 6MWD correlated with FEV1 among normal-weight asthmatics (r = 0.45, P = 0.04) and normal-weight non-asthmatics (r = 0.4, P = 0.03), but was not associated with BMI in either of the two groups. After adjusting for age, height, gender, and ethnicity, BMI was noted to be a significant predictor (β -2.76, 95% CI -4.77 to -0.76, P < 0.01) of the 6MWD among the obese while percent predicted FEV1 (β 1.87, 95% CI 0.28-3.45, P = 0.02) was a significant predictor among the normal-weight participants. Conclusions Our findings suggest that among urban minority obese asthmatic adolescents, functional exercise capacity was associated with obesity, rather than pulmonary function. Pediatr Pulmonol. 2012. 47:1061-1069.

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