Associations of Lipid Levels and Cognition: Findings from the Hispanic Community Health Study/Study of Latinos

Melissa Lamar, Ramon A. Durazo-Arvizu, Carlos J. Rodriguez, Robert C. Kaplan, Marisa J. Perera, Jianwen Cai, Rebeca A. Espinoza Giacinto, Hector M. González, Martha L. Daviglus

Research output: Contribution to journalArticle

Abstract

Objective: Hispanics/Latinos in the United States are less aware of their cholesterol levels and have a higher burden of associated adverse cardiovascular and cerebrovascular outcomes than non-Latino whites. Investigations of the associations between cholesterol levels and cognition in this population have often occurred within the context of metabolic syndrome and are limited to select lipids despite the fact that triglycerides (TGs) may be more relevant to the health of Hispanics/Latinos. Methods: Baseline data from the Hispanic Community Health Study/Study of Latinos, collected from 2008 to 2011, was used to investigate the associations of lipid levels (i.e., TG, total cholesterol, TC; low-density and high-density lipoprotein cholesterol, LDL-C and HDL-C) with cognition (i.e., learning, memory, verbal fluency, and digit symbol substitution, DSS), adjusting for relevant confounders. Results: In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p =.06). TC and LDL-C levels (separately) were positively associated with learning and verbal fluency regardless of adjustments (p-values <.05). Separate analyses investigating the effect modification by background and sex revealed a particularly robust association between TC levels and DSS performance for Puerto Ricans and Central Americans (albeit in opposite directions) and an inverse relationship between TG levels and DSS performance for women (p-values <.02). Conclusions: It is important to consider individual lipid levels and demographic characteristics when investigating associations between cholesterol levels and cognition in Hispanics/Latinos.

Original languageEnglish (US)
JournalJournal of the International Neuropsychological Society
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Hispanic Americans
Cognition
Lipids
Health
Triglycerides
Cholesterol
Verbal Learning
Linear Models
Social Adjustment
HDL Cholesterol
Cardiovascular Diseases
Demography

Keywords

  • Cholesterol
  • Cognition
  • Latinos
  • Learning
  • Memory
  • Triglycerides

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Associations of Lipid Levels and Cognition : Findings from the Hispanic Community Health Study/Study of Latinos. / Lamar, Melissa; Durazo-Arvizu, Ramon A.; Rodriguez, Carlos J.; Kaplan, Robert C.; Perera, Marisa J.; Cai, Jianwen; Espinoza Giacinto, Rebeca A.; González, Hector M.; Daviglus, Martha L.

In: Journal of the International Neuropsychological Society, 01.01.2019.

Research output: Contribution to journalArticle

Lamar, Melissa ; Durazo-Arvizu, Ramon A. ; Rodriguez, Carlos J. ; Kaplan, Robert C. ; Perera, Marisa J. ; Cai, Jianwen ; Espinoza Giacinto, Rebeca A. ; González, Hector M. ; Daviglus, Martha L. / Associations of Lipid Levels and Cognition : Findings from the Hispanic Community Health Study/Study of Latinos. In: Journal of the International Neuropsychological Society. 2019.
@article{af2c7d89db0e4bc39f60cbd60cfbac14,
title = "Associations of Lipid Levels and Cognition: Findings from the Hispanic Community Health Study/Study of Latinos",
abstract = "Objective: Hispanics/Latinos in the United States are less aware of their cholesterol levels and have a higher burden of associated adverse cardiovascular and cerebrovascular outcomes than non-Latino whites. Investigations of the associations between cholesterol levels and cognition in this population have often occurred within the context of metabolic syndrome and are limited to select lipids despite the fact that triglycerides (TGs) may be more relevant to the health of Hispanics/Latinos. Methods: Baseline data from the Hispanic Community Health Study/Study of Latinos, collected from 2008 to 2011, was used to investigate the associations of lipid levels (i.e., TG, total cholesterol, TC; low-density and high-density lipoprotein cholesterol, LDL-C and HDL-C) with cognition (i.e., learning, memory, verbal fluency, and digit symbol substitution, DSS), adjusting for relevant confounders. Results: In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p =.06). TC and LDL-C levels (separately) were positively associated with learning and verbal fluency regardless of adjustments (p-values <.05). Separate analyses investigating the effect modification by background and sex revealed a particularly robust association between TC levels and DSS performance for Puerto Ricans and Central Americans (albeit in opposite directions) and an inverse relationship between TG levels and DSS performance for women (p-values <.02). Conclusions: It is important to consider individual lipid levels and demographic characteristics when investigating associations between cholesterol levels and cognition in Hispanics/Latinos.",
keywords = "Cholesterol, Cognition, Latinos, Learning, Memory, Triglycerides",
author = "Melissa Lamar and Durazo-Arvizu, {Ramon A.} and Rodriguez, {Carlos J.} and Kaplan, {Robert C.} and Perera, {Marisa J.} and Jianwen Cai and {Espinoza Giacinto}, {Rebeca A.} and Gonz{\'a}lez, {Hector M.} and Daviglus, {Martha L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1017/S1355617719001000",
language = "English (US)",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Associations of Lipid Levels and Cognition

T2 - Findings from the Hispanic Community Health Study/Study of Latinos

AU - Lamar, Melissa

AU - Durazo-Arvizu, Ramon A.

AU - Rodriguez, Carlos J.

AU - Kaplan, Robert C.

AU - Perera, Marisa J.

AU - Cai, Jianwen

AU - Espinoza Giacinto, Rebeca A.

AU - González, Hector M.

AU - Daviglus, Martha L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: Hispanics/Latinos in the United States are less aware of their cholesterol levels and have a higher burden of associated adverse cardiovascular and cerebrovascular outcomes than non-Latino whites. Investigations of the associations between cholesterol levels and cognition in this population have often occurred within the context of metabolic syndrome and are limited to select lipids despite the fact that triglycerides (TGs) may be more relevant to the health of Hispanics/Latinos. Methods: Baseline data from the Hispanic Community Health Study/Study of Latinos, collected from 2008 to 2011, was used to investigate the associations of lipid levels (i.e., TG, total cholesterol, TC; low-density and high-density lipoprotein cholesterol, LDL-C and HDL-C) with cognition (i.e., learning, memory, verbal fluency, and digit symbol substitution, DSS), adjusting for relevant confounders. Results: In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p =.06). TC and LDL-C levels (separately) were positively associated with learning and verbal fluency regardless of adjustments (p-values <.05). Separate analyses investigating the effect modification by background and sex revealed a particularly robust association between TC levels and DSS performance for Puerto Ricans and Central Americans (albeit in opposite directions) and an inverse relationship between TG levels and DSS performance for women (p-values <.02). Conclusions: It is important to consider individual lipid levels and demographic characteristics when investigating associations between cholesterol levels and cognition in Hispanics/Latinos.

AB - Objective: Hispanics/Latinos in the United States are less aware of their cholesterol levels and have a higher burden of associated adverse cardiovascular and cerebrovascular outcomes than non-Latino whites. Investigations of the associations between cholesterol levels and cognition in this population have often occurred within the context of metabolic syndrome and are limited to select lipids despite the fact that triglycerides (TGs) may be more relevant to the health of Hispanics/Latinos. Methods: Baseline data from the Hispanic Community Health Study/Study of Latinos, collected from 2008 to 2011, was used to investigate the associations of lipid levels (i.e., TG, total cholesterol, TC; low-density and high-density lipoprotein cholesterol, LDL-C and HDL-C) with cognition (i.e., learning, memory, verbal fluency, and digit symbol substitution, DSS), adjusting for relevant confounders. Results: In 7413 participants ages 45 to 74 years from Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American backgrounds, separate, fully adjusted linear regression models revealed that TG levels were inversely associated with DSS performance; however, this relationship was no longer significant once additional cardiovascular disease risk factors were added to the model (p =.06). TC and LDL-C levels (separately) were positively associated with learning and verbal fluency regardless of adjustments (p-values <.05). Separate analyses investigating the effect modification by background and sex revealed a particularly robust association between TC levels and DSS performance for Puerto Ricans and Central Americans (albeit in opposite directions) and an inverse relationship between TG levels and DSS performance for women (p-values <.02). Conclusions: It is important to consider individual lipid levels and demographic characteristics when investigating associations between cholesterol levels and cognition in Hispanics/Latinos.

KW - Cholesterol

KW - Cognition

KW - Latinos

KW - Learning

KW - Memory

KW - Triglycerides

UR - http://www.scopus.com/inward/record.url?scp=85072654668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072654668&partnerID=8YFLogxK

U2 - 10.1017/S1355617719001000

DO - 10.1017/S1355617719001000

M3 - Article

AN - SCOPUS:85072654668

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

ER -