Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths

Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Christina M. Parrinello, Simin Hua, Mercedes R. Carnethon, Linda C. Gallo, Barry I. Hudson, Ronald B. Goldberg, Alan M. Delamater, Robert C. Kaplan, Carmen R. Isasi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

Original languageEnglish (US)
JournalJournal of Diabetes and its Complications
DOIs
StateAccepted/In press - Aug 23 2016

Fingerprint

Plasminogen Activator Inhibitor 1
Hispanic Americans
Hyperglycemia
Insulin Resistance
Biomarkers
E-Selectin
Fasting
Cardiovascular Diseases
Child Health
Glucose

Keywords

  • Adolescents/children
  • E-selectin
  • Hispanics
  • Hyyperglycemia
  • Insulin resistance
  • Plasminogen activator inhibitor-1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths : Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). / Parrinello, Christina M.; Hua, Simin; Carnethon, Mercedes R.; Gallo, Linda C.; Hudson, Barry I.; Goldberg, Ronald B.; Delamater, Alan M.; Kaplan, Robert C.; Isasi, Carmen R.

In: Journal of Diabetes and its Complications, 23.08.2016.

Research output: Contribution to journalArticle

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abstract = "Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95{\%} CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95{\%} CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.",
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AU - Hua, Simin

AU - Carnethon, Mercedes R.

AU - Gallo, Linda C.

AU - Hudson, Barry I.

AU - Goldberg, Ronald B.

AU - Delamater, Alan M.

AU - Kaplan, Robert C.

AU - Isasi, Carmen R.

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N2 - Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1316 children 8-16. years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥. 48.1 and ≥. 2.02. ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <. 0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09]). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

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