Associations of a Healthy Lifestyle Index With the Risks of Endometrial and Ovarian Cancer Among Women in the Women's Health Initiative Study

Rhonda Arthur, Theodore M. Brasky, Tracy E. Crane, Ashley S. Felix, Andrew M. Kaunitz, Aladdin H. Shadyab, Lihong Qi, Sylvia Wassertheil-Smoller, Thomas E. Rohan

Research output: Contribution to journalArticle

Abstract

Lifestyle-related factors influence risk of endometrial and ovarian cancers, but few studies have examined their joint associations with risk of these cancers. Using multivariable Cox regression models, we assessed the association of a healthy lifestyle index (HLI-a composite score (range, 0-20) involving diet, alcohol consumption, physical activity, body mass index, and smoking; higher scores represent healthier behavior) with risk of endometrial and ovarian cancers among 108,136 postmenopausal women who were recruited in the US Women's Health Initiative study between 1993 and 1998. After a median follow-up of 17.9 years, 1,435 endometrial cancer cases and 904 ovarian cancer cases had been ascertained. Women in the highest quintile of the HLI score had a lower risk of overall, type I, well-differentiated, moderately differentiated, poorly differentiated, and localized endometrial cancer than those in the lowest quintile (for quintile 5 vs. quintile 1, hazard ratio (HR) = 0.61 (95% CI: 0.51, 0.72), HR = 0.60 (95% CI: 0.49, 0.72), HR = 0.66 (95% CI: 0.46, 0.96), HR = 0.69 (95% CI: 0.52, 0.90), HR = 0.49 (95% CI: 0.34, 0.72), and HR = 0.61 (95% CI: 0.50, 0.74), respectively). The HLI score had a weak positive association with risk of serous ovarian cancer. Our findings underscore the potential importance of a healthy lifestyle in lowering endometrial cancer risk among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)261-273
Number of pages13
JournalAmerican Journal of Epidemiology
Volume188
Issue number2
DOIs
StatePublished - Feb 1 2019

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Women's Health
Endometrial Neoplasms
Ovarian Neoplasms
Risk-Taking
Proportional Hazards Models
Alcohol Drinking
Life Style
Body Mass Index
Smoking
Healthy Lifestyle
Exercise
Diet
Neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Associations of a Healthy Lifestyle Index With the Risks of Endometrial and Ovarian Cancer Among Women in the Women's Health Initiative Study. / Arthur, Rhonda; Brasky, Theodore M.; Crane, Tracy E.; Felix, Ashley S.; Kaunitz, Andrew M.; Shadyab, Aladdin H.; Qi, Lihong; Wassertheil-Smoller, Sylvia; Rohan, Thomas E.

In: American Journal of Epidemiology, Vol. 188, No. 2, 01.02.2019, p. 261-273.

Research output: Contribution to journalArticle

Arthur, Rhonda ; Brasky, Theodore M. ; Crane, Tracy E. ; Felix, Ashley S. ; Kaunitz, Andrew M. ; Shadyab, Aladdin H. ; Qi, Lihong ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E. / Associations of a Healthy Lifestyle Index With the Risks of Endometrial and Ovarian Cancer Among Women in the Women's Health Initiative Study. In: American Journal of Epidemiology. 2019 ; Vol. 188, No. 2. pp. 261-273.
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