Associations between fine particulate matter and changes in lipids/lipoproteins among midlife women

Xiangmei (May) Wu, Rachel Broadwin, Rupa Basu, Brian Malig, Keita Ebisu, Ellen B. Gold, Lihong Qi, Carol A. Derby, Sung Kyun Park, Shelley Green

Research output: Contribution to journalArticle

Abstract

Fine particles (PM2.5) are known to increase risks of cardiovascular diseases, but it is unclear how they affect plasma lipid levels. In this study, we examined the associations between PM2.5 exposure and lipid/lipoprotein levels from 2289 midlife women enrolled in the longitudinal Study of Women's Health Across the Nation. The average exposure to PM2.5 and gaseous co-pollutants during the prior one year, six months, 30 days, and one day were estimated for each woman based on U.S. Environmental Protection Agency ambient monitoring data. Blood samples were collected annually from 1999 to 2005 and analyzed for lipids/lipoproteins. Mixed-effect models were used to account for repeated measures for each woman, adjusted for demographic, health and behavior covariates. PM2.5 exposures, especially the long-term exposure, were negatively associated with protective lipoproteins, and positively associated with atherogenic lipoproteins. For example, each 3 μg/m3 increase of one-year PM2.5 exposure was associated with decreases of −0.7% (−1.4%, −0.1%) in high-density lipoprotein cholesterols and −0.6% (−1.1%, −0.1%) in apolipoprotein A1 (ApoA1), as well as increases of 3.8% (1.0%, 6.6%) in lipoprotein(a) and 1.4% (0.5%, 2.3%) in the ratio of apolipoprotein B (ApoB)/ApoA1. In stratified analysis, increased atherogenic lipoproteins were mainly observed in women without dyslipidemia, and both increased atherogenic lipoproteins and reduced protective lipoproteins were observed among women in perimenopause. In summary, PM2.5 exposure was associated with adverse lipid level changes, and thus, may increase cardiovascular risks in midlife women.

Original languageEnglish (US)
Pages (from-to)1179-1186
Number of pages8
JournalScience of the Total Environment
Volume654
DOIs
StatePublished - Mar 1 2019

Fingerprint

Lipoproteins
Particulate Matter
Lipids
particulate matter
lipid
womens health
cardiovascular disease
Lipoprotein(a)
Apolipoproteins
Apolipoprotein A-I
Environmental Protection Agency
Apolipoproteins B
woman
exposure
HDL Cholesterol
blood
Cholesterol
Blood
plasma
Health

Keywords

  • Dyslipidemia
  • Lipoprotein
  • Long-term exposure
  • Menopause
  • PM

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Associations between fine particulate matter and changes in lipids/lipoproteins among midlife women. / Wu, Xiangmei (May); Broadwin, Rachel; Basu, Rupa; Malig, Brian; Ebisu, Keita; Gold, Ellen B.; Qi, Lihong; Derby, Carol A.; Park, Sung Kyun; Green, Shelley.

In: Science of the Total Environment, Vol. 654, 01.03.2019, p. 1179-1186.

Research output: Contribution to journalArticle

Wu, Xiangmei (May) ; Broadwin, Rachel ; Basu, Rupa ; Malig, Brian ; Ebisu, Keita ; Gold, Ellen B. ; Qi, Lihong ; Derby, Carol A. ; Park, Sung Kyun ; Green, Shelley. / Associations between fine particulate matter and changes in lipids/lipoproteins among midlife women. In: Science of the Total Environment. 2019 ; Vol. 654. pp. 1179-1186.
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