Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese

Li Bian, Jian Dong Yang, Ting Wei Guo, Yun Duan, Wei Qin, Yun Sun, Guo Yin Feng, Lin He

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information. To date, numerous studies have investigated their possible association with AD but the results are controversial. Methods: To investigate the potential genetic contribution of the two genes in the Han Chinese population, we performed a case-control association study using 10 polymorphisms (4 in LRP1 and 6 in A2M) that span approximately the whole corresponding gene. Results: Comparison of allele, genotype, and haplotype frequencies for polymorphisms in A2M revealed no significant differences between patients and control subjects. For the LRP1 gene, however, we found an overrepresentation of the CTCG haplotype in the control group (p = .002). The difference was still of statistical significance in the apolipoprotein E (APOE) epsilon 4 negative subjects (pCTCG = .003). Multiple logistic regression analysis did not show any evidence of synergism between A2M, LRP1, and APOE. Conclusions: Our results indicate that the CTCG haplotype of LRP1 may reduce the risk of late-onset AD, but A2M is not associated with this disease in the Han Chinese population.

Original languageEnglish (US)
Pages (from-to)731-737
Number of pages7
JournalBiological Psychiatry
Volume58
Issue number9
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Fingerprint

Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
alpha-Macroglobulins
Alzheimer Disease
Haplotypes
Low Density Lipoprotein Receptor-Related Protein-6
Proteins
Genes
Apolipoprotein E4
Population
Case-Control Studies
Logistic Models
Alleles
Genotype
Regression Analysis
Control Groups

Keywords

  • A2M (alpha-2-macroglobulin)
  • Alzheimer disease
  • Association
  • Haplotype
  • Linkage disequilibrium
  • LRP1 (low-density lipoprotein receptor-related protein 1)

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Bian, L., Yang, J. D., Guo, T. W., Duan, Y., Qin, W., Sun, Y., ... He, L. (2005). Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese. Biological Psychiatry, 58(9), 731-737. https://doi.org/10.1016/j.biopsych.2005.05.013

Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese. / Bian, Li; Yang, Jian Dong; Guo, Ting Wei; Duan, Yun; Qin, Wei; Sun, Yun; Feng, Guo Yin; He, Lin.

In: Biological Psychiatry, Vol. 58, No. 9, 01.11.2005, p. 731-737.

Research output: Contribution to journalArticle

Bian, L, Yang, JD, Guo, TW, Duan, Y, Qin, W, Sun, Y, Feng, GY & He, L 2005, 'Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese', Biological Psychiatry, vol. 58, no. 9, pp. 731-737. https://doi.org/10.1016/j.biopsych.2005.05.013
Bian, Li ; Yang, Jian Dong ; Guo, Ting Wei ; Duan, Yun ; Qin, Wei ; Sun, Yun ; Feng, Guo Yin ; He, Lin. / Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese. In: Biological Psychiatry. 2005 ; Vol. 58, No. 9. pp. 731-737.
@article{ef660bf9e97b44d680056e921b29acd1,
title = "Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese",
abstract = "Background: Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information. To date, numerous studies have investigated their possible association with AD but the results are controversial. Methods: To investigate the potential genetic contribution of the two genes in the Han Chinese population, we performed a case-control association study using 10 polymorphisms (4 in LRP1 and 6 in A2M) that span approximately the whole corresponding gene. Results: Comparison of allele, genotype, and haplotype frequencies for polymorphisms in A2M revealed no significant differences between patients and control subjects. For the LRP1 gene, however, we found an overrepresentation of the CTCG haplotype in the control group (p = .002). The difference was still of statistical significance in the apolipoprotein E (APOE) epsilon 4 negative subjects (pCTCG = .003). Multiple logistic regression analysis did not show any evidence of synergism between A2M, LRP1, and APOE. Conclusions: Our results indicate that the CTCG haplotype of LRP1 may reduce the risk of late-onset AD, but A2M is not associated with this disease in the Han Chinese population.",
keywords = "A2M (alpha-2-macroglobulin), Alzheimer disease, Association, Haplotype, Linkage disequilibrium, LRP1 (low-density lipoprotein receptor-related protein 1)",
author = "Li Bian and Yang, {Jian Dong} and Guo, {Ting Wei} and Yun Duan and Wei Qin and Yun Sun and Feng, {Guo Yin} and Lin He",
year = "2005",
month = "11",
day = "1",
doi = "10.1016/j.biopsych.2005.05.013",
language = "English (US)",
volume = "58",
pages = "731--737",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "9",

}

TY - JOUR

T1 - Association study of the A2M and LRP1 genes with Alzheimer disease in the Han Chinese

AU - Bian, Li

AU - Yang, Jian Dong

AU - Guo, Ting Wei

AU - Duan, Yun

AU - Qin, Wei

AU - Sun, Yun

AU - Feng, Guo Yin

AU - He, Lin

PY - 2005/11/1

Y1 - 2005/11/1

N2 - Background: Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information. To date, numerous studies have investigated their possible association with AD but the results are controversial. Methods: To investigate the potential genetic contribution of the two genes in the Han Chinese population, we performed a case-control association study using 10 polymorphisms (4 in LRP1 and 6 in A2M) that span approximately the whole corresponding gene. Results: Comparison of allele, genotype, and haplotype frequencies for polymorphisms in A2M revealed no significant differences between patients and control subjects. For the LRP1 gene, however, we found an overrepresentation of the CTCG haplotype in the control group (p = .002). The difference was still of statistical significance in the apolipoprotein E (APOE) epsilon 4 negative subjects (pCTCG = .003). Multiple logistic regression analysis did not show any evidence of synergism between A2M, LRP1, and APOE. Conclusions: Our results indicate that the CTCG haplotype of LRP1 may reduce the risk of late-onset AD, but A2M is not associated with this disease in the Han Chinese population.

AB - Background: Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information. To date, numerous studies have investigated their possible association with AD but the results are controversial. Methods: To investigate the potential genetic contribution of the two genes in the Han Chinese population, we performed a case-control association study using 10 polymorphisms (4 in LRP1 and 6 in A2M) that span approximately the whole corresponding gene. Results: Comparison of allele, genotype, and haplotype frequencies for polymorphisms in A2M revealed no significant differences between patients and control subjects. For the LRP1 gene, however, we found an overrepresentation of the CTCG haplotype in the control group (p = .002). The difference was still of statistical significance in the apolipoprotein E (APOE) epsilon 4 negative subjects (pCTCG = .003). Multiple logistic regression analysis did not show any evidence of synergism between A2M, LRP1, and APOE. Conclusions: Our results indicate that the CTCG haplotype of LRP1 may reduce the risk of late-onset AD, but A2M is not associated with this disease in the Han Chinese population.

KW - A2M (alpha-2-macroglobulin)

KW - Alzheimer disease

KW - Association

KW - Haplotype

KW - Linkage disequilibrium

KW - LRP1 (low-density lipoprotein receptor-related protein 1)

UR - http://www.scopus.com/inward/record.url?scp=27544445273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27544445273&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2005.05.013

DO - 10.1016/j.biopsych.2005.05.013

M3 - Article

C2 - 16040006

AN - SCOPUS:27544445273

VL - 58

SP - 731

EP - 737

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 9

ER -