Abstract
To explore the relationship between vitamin A (retinol) deficiency and cervical squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women, we measured serum retinol concentrations in 1314 women enrolled in the Women's Interagency HIV Study and correlated the results with concurrent cervical cytology. At the baseline visit, 204 (15.5%) of the 1314 patients had retinol concentrations consistent with deficiency (<1.05 μmol/L). Analysis of Papanicolaou smears showed SILs in 216 (16.4%) of 1314 women. Cervical SILs were found to be associated with retinol concentrations <1.05 μmol/L (multivariate odds ratio [OR], 1.63; P = .04) in a multivariate model, which included human papillomavirus (HPV) status and markers of nutritional status and HIV disease stage. In the subset of women with genital HPV (n = 774), a multivariate analysis again revealed a significant independent association between retinol <1.05 μmol/L and cervical SILs (multivariate OR, 1.75; P = .02). Our findings suggest that retinol deficiency may contribute to the development of cervical SILs in HIV-infected women.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1084-1089 |
| Number of pages | 6 |
| Journal | Journal of Infectious Diseases |
| Volume | 182 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2000 |
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ASJC Scopus subject areas
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. / French, A. L.; Kirstein, L. M.; Massad, L. S.; Semba, R. D.; Minkoff, H.; Landesman, S.; Palefsky, J.; Young, M.; Anastos, Kathryn; Cohen, M. H.
In: Journal of Infectious Diseases, Vol. 182, No. 4, 2000, p. 1084-1089.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women
AU - French, A. L.
AU - Kirstein, L. M.
AU - Massad, L. S.
AU - Semba, R. D.
AU - Minkoff, H.
AU - Landesman, S.
AU - Palefsky, J.
AU - Young, M.
AU - Anastos, Kathryn
AU - Cohen, M. H.
PY - 2000
Y1 - 2000
N2 - To explore the relationship between vitamin A (retinol) deficiency and cervical squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women, we measured serum retinol concentrations in 1314 women enrolled in the Women's Interagency HIV Study and correlated the results with concurrent cervical cytology. At the baseline visit, 204 (15.5%) of the 1314 patients had retinol concentrations consistent with deficiency (<1.05 μmol/L). Analysis of Papanicolaou smears showed SILs in 216 (16.4%) of 1314 women. Cervical SILs were found to be associated with retinol concentrations <1.05 μmol/L (multivariate odds ratio [OR], 1.63; P = .04) in a multivariate model, which included human papillomavirus (HPV) status and markers of nutritional status and HIV disease stage. In the subset of women with genital HPV (n = 774), a multivariate analysis again revealed a significant independent association between retinol <1.05 μmol/L and cervical SILs (multivariate OR, 1.75; P = .02). Our findings suggest that retinol deficiency may contribute to the development of cervical SILs in HIV-infected women.
AB - To explore the relationship between vitamin A (retinol) deficiency and cervical squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women, we measured serum retinol concentrations in 1314 women enrolled in the Women's Interagency HIV Study and correlated the results with concurrent cervical cytology. At the baseline visit, 204 (15.5%) of the 1314 patients had retinol concentrations consistent with deficiency (<1.05 μmol/L). Analysis of Papanicolaou smears showed SILs in 216 (16.4%) of 1314 women. Cervical SILs were found to be associated with retinol concentrations <1.05 μmol/L (multivariate odds ratio [OR], 1.63; P = .04) in a multivariate model, which included human papillomavirus (HPV) status and markers of nutritional status and HIV disease stage. In the subset of women with genital HPV (n = 774), a multivariate analysis again revealed a significant independent association between retinol <1.05 μmol/L and cervical SILs (multivariate OR, 1.75; P = .02). Our findings suggest that retinol deficiency may contribute to the development of cervical SILs in HIV-infected women.
UR - http://www.scopus.com/inward/record.url?scp=0033795938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033795938&partnerID=8YFLogxK
U2 - 10.1086/315816
DO - 10.1086/315816
M3 - Article
C2 - 10979903
AN - SCOPUS:0033795938
VL - 182
SP - 1084
EP - 1089
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 4
ER -