Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women

A. L. French, L. M. Kirstein, L. S. Massad, R. D. Semba, H. Minkoff, S. Landesman, J. Palefsky, M. Young, Kathryn Anastos, M. H. Cohen

Research output: Contribution to journalArticle

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Abstract

To explore the relationship between vitamin A (retinol) deficiency and cervical squamous intraepithelial lesions (SILs) in human immunodeficiency virus (HIV)-infected women, we measured serum retinol concentrations in 1314 women enrolled in the Women's Interagency HIV Study and correlated the results with concurrent cervical cytology. At the baseline visit, 204 (15.5%) of the 1314 patients had retinol concentrations consistent with deficiency (<1.05 μmol/L). Analysis of Papanicolaou smears showed SILs in 216 (16.4%) of 1314 women. Cervical SILs were found to be associated with retinol concentrations <1.05 μmol/L (multivariate odds ratio [OR], 1.63; P = .04) in a multivariate model, which included human papillomavirus (HPV) status and markers of nutritional status and HIV disease stage. In the subset of women with genital HPV (n = 774), a multivariate analysis again revealed a significant independent association between retinol <1.05 μmol/L and cervical SILs (multivariate OR, 1.75; P = .02). Our findings suggest that retinol deficiency may contribute to the development of cervical SILs in HIV-infected women.

Original languageEnglish (US)
Pages (from-to)1084-1089
Number of pages6
JournalJournal of Infectious Diseases
Volume182
Issue number4
DOIs
StatePublished - 2000

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Vitamin A Deficiency
HIV
Vitamin A
Odds Ratio
Papanicolaou Test
Virus Diseases
Nutritional Status
Cell Biology
Squamous Intraepithelial Lesions of the Cervix
Multivariate Analysis
Serum

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

French, A. L., Kirstein, L. M., Massad, L. S., Semba, R. D., Minkoff, H., Landesman, S., ... Cohen, M. H. (2000). Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. Journal of Infectious Diseases, 182(4), 1084-1089. https://doi.org/10.1086/315816

Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. / French, A. L.; Kirstein, L. M.; Massad, L. S.; Semba, R. D.; Minkoff, H.; Landesman, S.; Palefsky, J.; Young, M.; Anastos, Kathryn; Cohen, M. H.

In: Journal of Infectious Diseases, Vol. 182, No. 4, 2000, p. 1084-1089.

Research output: Contribution to journalArticle

French, AL, Kirstein, LM, Massad, LS, Semba, RD, Minkoff, H, Landesman, S, Palefsky, J, Young, M, Anastos, K & Cohen, MH 2000, 'Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women', Journal of Infectious Diseases, vol. 182, no. 4, pp. 1084-1089. https://doi.org/10.1086/315816
French, A. L. ; Kirstein, L. M. ; Massad, L. S. ; Semba, R. D. ; Minkoff, H. ; Landesman, S. ; Palefsky, J. ; Young, M. ; Anastos, Kathryn ; Cohen, M. H. / Association of vitamin A deficiency with cervical squamous intraepithelial lesions in human immunodeficiency virus-infected women. In: Journal of Infectious Diseases. 2000 ; Vol. 182, No. 4. pp. 1084-1089.
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