Association of the IFNL4-ΔG allele with impaired spontaneous clearance of hepatitis C virus

Peter V. Aka, Mark H. Kuniholm, Ruth M. Pfeiffer, Alan S. Wang, Wei Tang, Sabrina Chen, Jacquie Astemborski, Michael Plankey, Maria C. Villacres, Marion G. Peters, Seema Desai, Eric C. Seaberg, Brian R. Edlin, Howard D. Strickler, David L. Thomas, Ludmila Prokunina-Olsson, Gerald B. Sharp, Thomas R. O'Brien

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10-5) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P =. 86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10-14) for IFNL4-TT/TT and 1.44 (P =. 03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalJournal of Infectious Diseases
Volume209
Issue number3
DOIs
StatePublished - Jan 24 2014

Keywords

  • HCV
  • IFNL4
  • IL28B
  • genetic
  • viral clearance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Aka, P. V., Kuniholm, M. H., Pfeiffer, R. M., Wang, A. S., Tang, W., Chen, S., Astemborski, J., Plankey, M., Villacres, M. C., Peters, M. G., Desai, S., Seaberg, E. C., Edlin, B. R., Strickler, H. D., Thomas, D. L., Prokunina-Olsson, L., Sharp, G. B., & O'Brien, T. R. (2014). Association of the IFNL4-ΔG allele with impaired spontaneous clearance of hepatitis C virus. Journal of Infectious Diseases, 209(3), 350-354. https://doi.org/10.1093/infdis/jit433