Association of subclinical atherosclerosis with lipid levels amongst antiretroviral-treated and untreated HIV-infected women in the Women's Interagency HIV study

Christina M. Parrinello, Alan L. Landay, Howard N. Hodis, Stephen J. Gange, Philip J. Norris, Mary Young, Kathryn Anastos, Phyllis C. Tien, Xiaonan Xue, Jason Lazar, Lorie Benning, Russell P. Tracy, Robert C. Kaplan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: We examined serum lipids in association with carotid artery intima-media thickness (CIMT) in HIV-infected and HIV-uninfected women. Methods: In 2003-4, among 1827 Women's Interagency HIV Study participants, we measured CIMT and lipids (high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), non-HDL-c). A subset of 520 treated HIV-infected women had pre-1997 lipid measures. We used multivariable linear regression to examine associations between lipids and CIMT. Results: In HIV-uninfected women, higher TC, LDL-c and non-HDL-c were associated with increased CIMT. Among HIV-infected women, associations of lipids with CIMT were observed in treated but not untreated women. Among the HIV-infected women treated in 2003-4, CIMT was associated both with lipids measured a decade earlier in infection, and with late lipid measurements. Conclusion: Among HIV-infected women, hyperlipidemia is most strongly associated with subclinical atherosclerosis in treated women. Among treated women, the association appeared strongest early in the disease course.

Original languageEnglish (US)
Pages (from-to)408-411
Number of pages4
JournalAtherosclerosis
Volume225
Issue number2
DOIs
StatePublished - Dec 1 2012

Keywords

  • Cardiovascular diseases
  • Carotid arteries
  • HAART
  • HIV
  • Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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