Association of Streptococcus bovis with carcinoma of the colon

R. S. Klein, R. A. Recco, Michela T. Catalano, S. C. Edberg, J. I. Casey, N. H. Steigbigel

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Abstract

Two patients with colonic adenocarcinoma and Streptococcus bovis endocarditis suggested a possible association between the two. Non-enterococcal Group D streptococci were isolated from fecal cultures of 11 of 105 controls, 35 of 63 patients with carcinoma of the colon, seven of 25 with inflammatory bowel disease, four of 21 with non-colonic neoplasms and five of 37 with other gastrointestinal disorders. All such streptococci examined for lactose fermentation were S. bovis. The prevalence of S. bovis in fecal cultures from patients with carcinoma of the colon was significantly increased (P<0.001) as compared to that in controls, and also to all other groups (P<0.001). No other group had results significantly different from those of controls (P>0.05) although patients with inflammatory bowel disease were more frequently carriers. The carrier state was unrelated to age, hospitalisation status, colonic stasis, gastrointestinal bleeding or recent barium-enema examination. The implications of this association are unknown.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalNew England Journal of Medicine
Volume297
Issue number15
StatePublished - 1977

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Streptococcus bovis
Colon
Carcinoma
Carrier State
Enterococcus faecalis
Lactose
Endocarditis
Streptococcus
Inflammatory Bowel Diseases
Fermentation
Adenocarcinoma
Hospitalization
Hemorrhage
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Klein, R. S., Recco, R. A., Catalano, M. T., Edberg, S. C., Casey, J. I., & Steigbigel, N. H. (1977). Association of Streptococcus bovis with carcinoma of the colon. New England Journal of Medicine, 297(15), 800-802.

Association of Streptococcus bovis with carcinoma of the colon. / Klein, R. S.; Recco, R. A.; Catalano, Michela T.; Edberg, S. C.; Casey, J. I.; Steigbigel, N. H.

In: New England Journal of Medicine, Vol. 297, No. 15, 1977, p. 800-802.

Research output: Contribution to journalArticle

Klein, RS, Recco, RA, Catalano, MT, Edberg, SC, Casey, JI & Steigbigel, NH 1977, 'Association of Streptococcus bovis with carcinoma of the colon', New England Journal of Medicine, vol. 297, no. 15, pp. 800-802.
Klein RS, Recco RA, Catalano MT, Edberg SC, Casey JI, Steigbigel NH. Association of Streptococcus bovis with carcinoma of the colon. New England Journal of Medicine. 1977;297(15):800-802.
Klein, R. S. ; Recco, R. A. ; Catalano, Michela T. ; Edberg, S. C. ; Casey, J. I. ; Steigbigel, N. H. / Association of Streptococcus bovis with carcinoma of the colon. In: New England Journal of Medicine. 1977 ; Vol. 297, No. 15. pp. 800-802.
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AU - Recco, R. A.

AU - Catalano, Michela T.

AU - Edberg, S. C.

AU - Casey, J. I.

AU - Steigbigel, N. H.

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