Association of past and recent major depression and menstrual characteristics in midlife: Study of Women's Health Across the Nation

Joyce T. Bromberger, Laura L. Schott, Karen A. Matthews, Howard M. Kravitz, John F. Randolph, Sioban Harlow, Sybil Crawford, Robin Green, Hadine Joffe

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Objective: The aim of this study was to examine the association of a history of major depression (MD) with menstrual problems in a multiethnic sample of midlife women. METHODS: Participants were 934 women enrolled in the Study of Women's Health Across the Nation, a multisite study of menopause and aging. The outcomes were menstrual bleeding problems and premenstrual symptoms in the year before study entry. The Structured Clinical Interview for the Diagnosis of DSM-IV Axis I Disorders was conducted to determine recent and past psychiatric diagnoses. Covariates included sociodemographic, behavioral, and gynecologic factors. RESULTS: One third of the participants reported heavy bleeding, 20% reported other abnormal bleeding, and 18% reported premenstrual symptoms. One third had past and 11% had recent MD. Past MD was associated with an increased likelihood of heavy bleeding (odds ratio, 1.89; 95% CI, 1.25-2.85), adjusting for recent MD, menopause status, and other covariates. Past MD was not associated with other abnormal bleeding or premenstrual symptoms in the final analysis that adjusted for recent MD. Conclusions: Midlife women with a history of MD are more likely to report heavy bleeding.

Original languageEnglish (US)
Pages (from-to)959-966
Number of pages8
JournalMenopause
Volume19
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Bleeding
  • Major depression
  • Menstrual cycle
  • Midlife

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Bromberger, J. T., Schott, L. L., Matthews, K. A., Kravitz, H. M., Randolph, J. F., Harlow, S., Crawford, S., Green, R., & Joffe, H. (2012). Association of past and recent major depression and menstrual characteristics in midlife: Study of Women's Health Across the Nation. Menopause, 19(9), 959-966. https://doi.org/10.1097/gme.0b013e318248f2d5