Association of MLL amplification with poor outcome in acute myeloid leukemia

Robert W. Maitta, Linda A. Cannizzaro, K.h. Ramesh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chromosomal rearrangements and amplification of the MLL gene at 11q23 are common abnormalities found in patients with severe myelodysplastic disorders and lymphoid and acute myeloid leukemias. MLL rearrangements are associated with aggressive disease in both children and adults, with current evidence suggesting that MLL alterations are associated with a poor prognosis. We report the clinical, cytogenetic and histologic findings of a patient who presented with a de novo diagnosis of AML-M4 and who fits the profile of patients presenting with MLL alterations, such as old age at presentation, rapid progression, therapeutic refractoriness, and poor outcome. Two bone marrow specimens taken 1 month apart show the rapid deterioration of the patient's cytogenetic abnormalities at the 11q23 locus, with amplification of MLL that was originally seen as a homogeneously staining region (hsr) on chromosome 11. In the second biopsy the hsr and MLL amplification appears as nonreciprocal translocation of multiple copies in the form of marked amplification of MLL on chromosome 16 in a background of increasing chromosomal aberrations. This case suggests that either the MLL amplification and translocation alone or in conjunction with other flanking oncogenes may have played an important role in poor patient outcome.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume192
Issue number1
DOIs
StatePublished - Jul 1 2009

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Acute Myeloid Leukemia
Chromosome Aberrations
Staining and Labeling
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 11
Gene Amplification
Oncogenes
Cytogenetics
Bone Marrow
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Association of MLL amplification with poor outcome in acute myeloid leukemia. / Maitta, Robert W.; Cannizzaro, Linda A.; Ramesh, K.h.

In: Cancer Genetics and Cytogenetics, Vol. 192, No. 1, 01.07.2009, p. 40-43.

Research output: Contribution to journalArticle

Maitta, Robert W. ; Cannizzaro, Linda A. ; Ramesh, K.h. / Association of MLL amplification with poor outcome in acute myeloid leukemia. In: Cancer Genetics and Cytogenetics. 2009 ; Vol. 192, No. 1. pp. 40-43.
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