Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men

David B. Hanna, Juan Lin, Wendy S. Post, Howard N. Hodis, Xiaonan Xue, Kathryn Anastos, Mardge H. Cohen, Stephen J. Gange, Sabina A. Haberlen, Sonya L. Heath, Jason M. Lazar, Chenglong Liu, Wendy J. Mack, Igho Ofotokun, Frank J. Palella, Phyllis C. Tien, Mallory D. Witt, Alan L. Landay, Lawrence A. Kingsley, Russell P. TracyRobert C. Kaplan

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background. Monocytes and monocyte-derived macrophages promote atherosclerosis through increased inflammation and vascular remodeling. This may be especially true in chronic human immunodeficiency virus (HIV) infection. Methods. We examined 778 women (74% HIV+) in the Women's Interagency HIV Study and 503 men (65% HIV+) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. We assessed baseline associations of the serum macrophage inflammation markers soluble (s)CD163, sCD14, galectin-3 (Gal-3), and Gal-3 binding protein (Gal-3BP) with carotid plaque formation (focal intima-media thickness >1.5 mm) over 7 years. Results. Marker levels were higher in HIV+ persons versus HIV- persons. Presence of focal plaque increased over time: From 8% to 15% in women, and 24% to 34% in men. After adjustment for demographic, behavioral, and cardiometabolic factors, and CRP and interleukin-6, each standard deviation increase in sCD14 was associated with increased plaque formation (risk ratio [RR] 1.24, 95% confidence interval [CI] 1.07-1.43). This pattern was consistentby sex. sCD163 was associated with plaque formation in virally suppressed HIV+ men (RR 1.52, 95% CI 1.04-2.22); Gal-3BP and Gal-3 were not associated with increased plaque. Conclusions. sCD14 and sCD163 may play important roles in atherogenesis among HIV+ persons.

Original languageEnglish (US)
Pages (from-to)1352-1361
Number of pages10
JournalJournal of Infectious Diseases
Volume215
Issue number9
DOIs
StatePublished - Jan 1 2017

Keywords

  • HIV infection
  • atherosclerosis
  • galectin-3
  • galectin-3 binding protein
  • inflammation
  • intima-media thickness
  • macrophages
  • monocytes
  • soluble CD14
  • soluble CD163

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Hanna, D. B., Lin, J., Post, W. S., Hodis, H. N., Xue, X., Anastos, K., Cohen, M. H., Gange, S. J., Haberlen, S. A., Heath, S. L., Lazar, J. M., Liu, C., Mack, W. J., Ofotokun, I., Palella, F. J., Tien, P. C., Witt, M. D., Landay, A. L., Kingsley, L. A., ... Kaplan, R. C. (2017). Association of macrophage inflammation biomarkers with progression of subclinical carotid artery atherosclerosis in HIV-infected women and men. Journal of Infectious Diseases, 215(9), 1352-1361. https://doi.org/10.1093/infdis/jix082