TY - JOUR
T1 - Association of human immunodeficiency virus (HIV) load early in life with disease progression among HIV-infected infants
AU - Abrams, Elaine J.
AU - Weedon, Jeremy
AU - Steketee, Richard W.
AU - Lambert, Genevieve
AU - Bamji, Mahrukh
AU - Brown, Theresa
AU - Kalish, Marcia L.
AU - Schoenbaum, Ellie E.
AU - Thomas, Pauline A.
AU - Thea, Donald M.
N1 - Funding Information:
Received 20 June 1997; revised 14 January 1998. Presented in part: XI International Conference on AIDS, Vancouver, Canada, 7±12 July 1996. Informed consent was obtained from all study participants, according to the guidelines of the US Department of Health and Human Services and those of the institutional review boards of the New York City Department of Health, Medical and Health Research Association, Inc., and the individual study hospitals. The use of trade names is for identi®cation only and does not imply endorsement by the Public Health Service or the US Department of Health and Human Services. Financial support: CDC (cooperative agreement U64 CCU 200937) through a grant to Medical and Health Research Association of New York City, Inc. Reprints or correspondence: Dr. Elaine J. Abrams, Dept. of Pediatrics, Harlem Hospital Center, 506 Lenox Ave., New York, NY 10037 (eja1@ columbia.edu). * Study group members are listed after text.
PY - 1998
Y1 - 1998
N2 - The utility of RNA virus load to predict progression of human immunodeficiency virus (HIV)-1 disease was assessed in 89 HIV-1-infected children. Of 22 virus load values during week 1 of life, 17 were below the detection threshold. Geometric mean virus load increased to ~7 x 105 copies/mL by week 4, was sustained throughout the first 6 months of life, and then declined to 1.6 x 105 copies/mL during the third year. Samples from week I of life had little predictive value, but virus load during days 7-30 strongly predicted progression to CDC-3 classification or death (P = .024; risk ratio = 1.6), and virus load during months 2-3 predicted progression to CDC-C or death within the first 6 months of life (P = .002, risk ratio = 11). Virus load was highly associated with imminent vulnerability to CDC-C or death (P = .002) during the first 18 months of life. Except for values from the first week of life, virus load at any age through 18 months is strongly associated with risk of HIV disease progression.
AB - The utility of RNA virus load to predict progression of human immunodeficiency virus (HIV)-1 disease was assessed in 89 HIV-1-infected children. Of 22 virus load values during week 1 of life, 17 were below the detection threshold. Geometric mean virus load increased to ~7 x 105 copies/mL by week 4, was sustained throughout the first 6 months of life, and then declined to 1.6 x 105 copies/mL during the third year. Samples from week I of life had little predictive value, but virus load during days 7-30 strongly predicted progression to CDC-3 classification or death (P = .024; risk ratio = 1.6), and virus load during months 2-3 predicted progression to CDC-C or death within the first 6 months of life (P = .002, risk ratio = 11). Virus load was highly associated with imminent vulnerability to CDC-C or death (P = .002) during the first 18 months of life. Except for values from the first week of life, virus load at any age through 18 months is strongly associated with risk of HIV disease progression.
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U2 - 10.1086/515596
DO - 10.1086/515596
M3 - Article
C2 - 9652428
AN - SCOPUS:17344372636
SN - 0022-1899
VL - 178
SP - 101
EP - 108
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -
