TY - JOUR
T1 - Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
AU - FIoris-Moore, Michelle
AU - Fayad, Zahi A.
AU - Berman, Joan W.
AU - Mani, Venkatesh
AU - Schoenbaum, Ellie E.
AU - Klein, Robert S.
AU - Weinshelbaum, Karen B.
AU - Fuster, Valentin
AU - Howard, Andrea A.
AU - Lo, Yungtai
AU - Schecter, Alison D.
PY - 2009/5/15
Y1 - 2009/5/15
N2 - Background: HIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. Objective: To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. Design: A cross-sectional analysis. Methods: Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Results: Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P=0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterokhigh-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/ CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P<0.01) and vessel wall thickness (VWT, P=0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P<0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P=0.01). Conclusion: HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
AB - Background: HIV-infected individuals may be at increased risk for atherosclerosis. Although this is partially attributable to metabolic factors, HIV-associated inflammation may play a role. Objective: To investigate associations of HIV disease with serum monocyte chemoattractant protein-1/chemokine (C-C motif) ligand 2 (MCP-1/CCL2) levels and atherosclerosis burden. Design: A cross-sectional analysis. Methods: Serum MCP-1/CCL2, fasting lipids, and glucose tolerance were measured in 98 HIV-infected and 79 demographically similar uninfected adults. Eighty-four participants had MRI of the carotid arteries and thoracic aorta to measure atherosclerosis burden. Multivariate analyses were performed using linear regression. Results: Mean MCP-1/CCL2 levels did not differ between HIV-infected and uninfected participants (P = 0.65). Among HIV-infected participants, after adjusting for age, BMI, and cigarette smoking, HIV-1 viral load was positively associated with MCP-1/CCL2 (P=0.02). Multivariate analyses adjusting for sex, low-density lipoprotein cholesterol, total cholesterokhigh-density lipoprotein cholesterol ratio, cigarette smoking, MCP-1/ CCL2, and protease inhibitor use found that HIV infection was associated with greater mean thoracic aorta vessel wall area (VWA, P<0.01) and vessel wall thickness (VWT, P=0.03), but not with carotid artery parameters. Compared with being uninfected, having detectable HIV-1 viremia was associated with greater mean thoracic aorta VWA (P<0.01) and VWT (P = 0.03), whereas being HIV-infected with undetectable viral load was associated with greater thoracic aorta VWA (P = 0.02) but not VWT (P = 0.15). There was an independent positive association of MCP-1/CCL2 with thoracic aorta VWA (P = 0.01) and VWT (P=0.01). Conclusion: HIV-1 viral burden is associated with higher serum levels of MCP-1/CCL2 and with atherosclerosis burden, as assessed by thoracic aorta VWA and VWT.
UR - http://www.scopus.com/inward/record.url?scp=67049156210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67049156210&partnerID=8YFLogxK
U2 - 10.1097/QAD.0b013e328329c76b
DO - 10.1097/QAD.0b013e328329c76b
M3 - Article
C2 - 19318907
AN - SCOPUS:67049156210
SN - 0269-9370
VL - 23
SP - 941
EP - 949
JO - AIDS
JF - AIDS
IS - 8
ER -
