Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

Niall Buckley, Ashley Huber, Yungtai Lo, Philip E. Castle, Kimdar Kemal, Robert D. Burk, Howard Strickler, Mark H. Einstein, Mary Young, Kathryn Anastos, Betsy Herold

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P <0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVB al activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVB aL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Immunologic Factors
HIV
Human papillomavirus 16
Viral Load
Interleukin-1
RNA
Therapeutic Irrigation
CD4 Lymphocyte Count
Cross-Sectional Studies
Genotype
T-Lymphocytes
DNA
Health

Keywords

  • Cervicovaginal immunity
  • Defensins
  • HIV
  • Human papillomavirus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women. / Buckley, Niall; Huber, Ashley; Lo, Yungtai; Castle, Philip E.; Kemal, Kimdar; Burk, Robert D.; Strickler, Howard; Einstein, Mark H.; Young, Mary; Anastos, Kathryn; Herold, Betsy.

In: American Journal of Reproductive Immunology, Vol. 75, No. 2, 01.02.2016, p. 146-154.

Research output: Contribution to journalArticle

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abstract = "Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P <0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVB al activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVB aL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.",
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