Association of High-Risk Human Papillomavirus with Genital Tract Mucosal Immune Factors in HIV-Infected Women

Niall Buckley, Ashley Huber, Yungtai Lo, Philip E. Castle, Kimdar Kemal, Robert D. Burk, Howard D. Strickler, Mark H. Einstein, Mary Young, Kathryn Anastos, Betsy C. Herold

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Problem: High-risk human papillomavirus (HR-HPV) is prevalent in HIV-infected women and may be associated with mucosal changes that promote HIV replication. Method of study: Innate immune molecules, antimicrobial activity, HIV RNA, and HPV DNA genotypes were measured in a cross-sectional study of 128 HIV-infected women categorized into HPV-16 (n = 8), other HR-HPV (n = 41), and non-HR-HPV controls (n = 79). Results: Compared to controls, HR-HPV groups had higher plasma viral loads (P = 0.004), lower CD4 cells (P = 0.02), more genital tract HIV RNA (P = 0.03), greater number of different HPV types (P < 0.001), higher cervicovaginal lavage (CVL) IL-1α (P = 0.03) and human beta-defensin 2 (HBD2) (P = 0.049), and less anti-HIVBal activity (P = 0.03). HPV-16 remained significantly associated with higher HBD2 (P = 0.03), higher IL-1α (P = 0.009), and lower anti-HIVBaL activity (P = 0.03) compared to controls after adjusting for plasma viral load and CD4 T cell count. Conclusion: HR-HPV is associated with mucosal changes in HIV-infected women that could adversely impact genital tract health.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Volume75
Issue number2
DOIs
StatePublished - Feb 1 2016

    Fingerprint

Keywords

  • Cervicovaginal immunity
  • Defensins
  • HIV
  • Human papillomavirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this