Association of guideline-adherent antibiotic treatment with readmission of children with sickle cell disease hospitalized with acute chest syndrome

David G. Bundy, Troy E. Richardson, Matthew Hall, Jean L. Raphael, David C. Brousseau, Staci D. Arnold, Ram V. Kalpatthi, Angela M. Ellison, Suzette Olu Busola Oyeku, Samir S. Shah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

IMPORTANCE: Acute chest syndrome (ACS) is a common, serious complication of sickle cell disease (SCD) and a leading cause of hospitalization and death in both children and adults with SCD. Little is known about the effectiveness of guideline-recommended antibiotic regimens for the care of children hospitalized with ACS. OBJECTIVES: To use a large, national database to describe patterns of antibiotic use for children with SCD hospitalized for ACS and to determine whether receipt of guideline-adherent antibiotics was associated with lower readmission rates. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study including 14 480 hospitalizations in 7178 children (age 0-22 years) with a discharge diagnosis of SCD and eithe ACS or pneumonia. Information was obtained from 41 children’s hospitals submitting data to the Pediatric Health Information System from January 1, 2010, to December 31, 2016. EXPOSURES: National Heart, Lung, and Blood Institute guideline-adherent (macrolide with parenteral cephalosporin) vs non–guideline-adherent antibiotic regimens. MAIN OUTCOMES AND MEASURES: Acute chest syndrome–related and all-cause 7- and 30-day readmissions. RESULTS: Of the 14 480 hospitalizations, 6562 (45.3%) were in girls; median (interquartile range) age was 9 (4-14) years. Guideline-adherent antibiotics were provided in 10 654 of 14 480 hospitalizations for ACS (73.6%). Hospitalizations were most likely to include guideline-adherent antibiotics for children aged 5 to 9 years (3230 of 4047 [79.8%]) and declined to the lowest level for children 19 to 22 years (697 of 1088 [64.1%]). Between-hospital variation in antibiotic regimens was wide, with use of guideline-adherent antibiotics ranging from 24% to 90%. Children treated with guideline-adherent antibiotics had lower 30-day ACS-related (odds ratio [OR], 0.71; 95% CI, 0.50-1.00) and all-cause (OR, 0.50; 95% CI, 0.39-0.64) readmission rates vs children who received other regimens (cephalosporin and macrolide vs neither drug class). CONCLUSIONS AND RELEVANCE: Current approaches to antibiotic treatment in children with ACS vary widely, but guideline-adherent therapy appears to result in fewer readmissions compared with non–guideline-adherent therapy. Efforts to increase the dissemination and implementation of SCD treatment guidelines are warranted as is comparative effectiveness research to strengthen the underlying evidence base.

Original languageEnglish (US)
Pages (from-to)1090-1099
Number of pages10
JournalJAMA Pediatrics
Volume171
Issue number11
DOIs
StatePublished - Nov 1 2017

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Acute Chest Syndrome
Sickle Cell Anemia
Guidelines
Anti-Bacterial Agents
Hospitalization
Therapeutics
Macrolides
Cephalosporins
Odds Ratio
Comparative Effectiveness Research
National Heart, Lung, and Blood Institute (U.S.)
Health Information Systems
Hospitalized Child
Child Care
Cause of Death
Pneumonia
Cohort Studies
Thorax
Retrospective Studies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Bundy, D. G., Richardson, T. E., Hall, M., Raphael, J. L., Brousseau, D. C., Arnold, S. D., ... Shah, S. S. (2017). Association of guideline-adherent antibiotic treatment with readmission of children with sickle cell disease hospitalized with acute chest syndrome. JAMA Pediatrics, 171(11), 1090-1099. https://doi.org/10.1001/jamapediatrics.2017.2526

Association of guideline-adherent antibiotic treatment with readmission of children with sickle cell disease hospitalized with acute chest syndrome. / Bundy, David G.; Richardson, Troy E.; Hall, Matthew; Raphael, Jean L.; Brousseau, David C.; Arnold, Staci D.; Kalpatthi, Ram V.; Ellison, Angela M.; Oyeku, Suzette Olu Busola; Shah, Samir S.

In: JAMA Pediatrics, Vol. 171, No. 11, 01.11.2017, p. 1090-1099.

Research output: Contribution to journalArticle

Bundy, DG, Richardson, TE, Hall, M, Raphael, JL, Brousseau, DC, Arnold, SD, Kalpatthi, RV, Ellison, AM, Oyeku, SOB & Shah, SS 2017, 'Association of guideline-adherent antibiotic treatment with readmission of children with sickle cell disease hospitalized with acute chest syndrome', JAMA Pediatrics, vol. 171, no. 11, pp. 1090-1099. https://doi.org/10.1001/jamapediatrics.2017.2526
Bundy, David G. ; Richardson, Troy E. ; Hall, Matthew ; Raphael, Jean L. ; Brousseau, David C. ; Arnold, Staci D. ; Kalpatthi, Ram V. ; Ellison, Angela M. ; Oyeku, Suzette Olu Busola ; Shah, Samir S. / Association of guideline-adherent antibiotic treatment with readmission of children with sickle cell disease hospitalized with acute chest syndrome. In: JAMA Pediatrics. 2017 ; Vol. 171, No. 11. pp. 1090-1099.
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abstract = "IMPORTANCE: Acute chest syndrome (ACS) is a common, serious complication of sickle cell disease (SCD) and a leading cause of hospitalization and death in both children and adults with SCD. Little is known about the effectiveness of guideline-recommended antibiotic regimens for the care of children hospitalized with ACS. OBJECTIVES: To use a large, national database to describe patterns of antibiotic use for children with SCD hospitalized for ACS and to determine whether receipt of guideline-adherent antibiotics was associated with lower readmission rates. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study including 14 480 hospitalizations in 7178 children (age 0-22 years) with a discharge diagnosis of SCD and eithe ACS or pneumonia. Information was obtained from 41 children’s hospitals submitting data to the Pediatric Health Information System from January 1, 2010, to December 31, 2016. EXPOSURES: National Heart, Lung, and Blood Institute guideline-adherent (macrolide with parenteral cephalosporin) vs non–guideline-adherent antibiotic regimens. MAIN OUTCOMES AND MEASURES: Acute chest syndrome–related and all-cause 7- and 30-day readmissions. RESULTS: Of the 14 480 hospitalizations, 6562 (45.3{\%}) were in girls; median (interquartile range) age was 9 (4-14) years. Guideline-adherent antibiotics were provided in 10 654 of 14 480 hospitalizations for ACS (73.6{\%}). Hospitalizations were most likely to include guideline-adherent antibiotics for children aged 5 to 9 years (3230 of 4047 [79.8{\%}]) and declined to the lowest level for children 19 to 22 years (697 of 1088 [64.1{\%}]). Between-hospital variation in antibiotic regimens was wide, with use of guideline-adherent antibiotics ranging from 24{\%} to 90{\%}. Children treated with guideline-adherent antibiotics had lower 30-day ACS-related (odds ratio [OR], 0.71; 95{\%} CI, 0.50-1.00) and all-cause (OR, 0.50; 95{\%} CI, 0.39-0.64) readmission rates vs children who received other regimens (cephalosporin and macrolide vs neither drug class). CONCLUSIONS AND RELEVANCE: Current approaches to antibiotic treatment in children with ACS vary widely, but guideline-adherent therapy appears to result in fewer readmissions compared with non–guideline-adherent therapy. Efforts to increase the dissemination and implementation of SCD treatment guidelines are warranted as is comparative effectiveness research to strengthen the underlying evidence base.",
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AU - Brousseau, David C.

AU - Arnold, Staci D.

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N2 - IMPORTANCE: Acute chest syndrome (ACS) is a common, serious complication of sickle cell disease (SCD) and a leading cause of hospitalization and death in both children and adults with SCD. Little is known about the effectiveness of guideline-recommended antibiotic regimens for the care of children hospitalized with ACS. OBJECTIVES: To use a large, national database to describe patterns of antibiotic use for children with SCD hospitalized for ACS and to determine whether receipt of guideline-adherent antibiotics was associated with lower readmission rates. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study including 14 480 hospitalizations in 7178 children (age 0-22 years) with a discharge diagnosis of SCD and eithe ACS or pneumonia. Information was obtained from 41 children’s hospitals submitting data to the Pediatric Health Information System from January 1, 2010, to December 31, 2016. EXPOSURES: National Heart, Lung, and Blood Institute guideline-adherent (macrolide with parenteral cephalosporin) vs non–guideline-adherent antibiotic regimens. MAIN OUTCOMES AND MEASURES: Acute chest syndrome–related and all-cause 7- and 30-day readmissions. RESULTS: Of the 14 480 hospitalizations, 6562 (45.3%) were in girls; median (interquartile range) age was 9 (4-14) years. Guideline-adherent antibiotics were provided in 10 654 of 14 480 hospitalizations for ACS (73.6%). Hospitalizations were most likely to include guideline-adherent antibiotics for children aged 5 to 9 years (3230 of 4047 [79.8%]) and declined to the lowest level for children 19 to 22 years (697 of 1088 [64.1%]). Between-hospital variation in antibiotic regimens was wide, with use of guideline-adherent antibiotics ranging from 24% to 90%. Children treated with guideline-adherent antibiotics had lower 30-day ACS-related (odds ratio [OR], 0.71; 95% CI, 0.50-1.00) and all-cause (OR, 0.50; 95% CI, 0.39-0.64) readmission rates vs children who received other regimens (cephalosporin and macrolide vs neither drug class). CONCLUSIONS AND RELEVANCE: Current approaches to antibiotic treatment in children with ACS vary widely, but guideline-adherent therapy appears to result in fewer readmissions compared with non–guideline-adherent therapy. Efforts to increase the dissemination and implementation of SCD treatment guidelines are warranted as is comparative effectiveness research to strengthen the underlying evidence base.

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