Association of DXA-derived bone mineral density and fat mass with african ancestry

Heather M. Ochs-Balcom, Leah Preus, Jean Wactawski-Wende, Jing Nie, Nicholas A. Johnson, Fouad Zakharia, Hua Tang, Chris Carlson, Cara Carty, Zhao Chen, Thomas Hoffman, Carolyn M. Hutter, Rebecca D. Jackson, Robert C. Kaplan, Li Li, Song Liu, Marian L. Neuhouser, Ulrike Peters, John Robbins, Michael F. Seldin & 4 others Timothy A. Thornton, Cheryl L. Thompson, Charles Kooperberg, Lara E. Sucheston

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Context: Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups. Objective: We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry. Setting/Participants: We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available. Methods: We derived both global and local ancestry estimates for each individual from Affymetrix 6.0 data and analyzed the correlation of DXA phenotypes with global African ancestry. For each phenotype, we examined the association of local genetic ancestry (number of African ancestral alleles at each marker) and each DXA phenotype at 570 282 markers acrossthe genome in additive models with adjustment for important covariates. Results: We identified statistically significant correlations of whole-body fat mass, trunk fat mass, and all 6 measures of BMD with a proportion of African ancestry. Genome-wide (admixture) significance for femoral neck BMD was achieved across 2 regions -3.7 MB and 0.3 MB on chromosome 19q13; similarly, total hip and intertrochanter BMD were associated with local ancestry in these regions. Trunk fat was the most significant fat mass phenotype showing strong, but not genomewide significant associations on chromosome Xp22. Conclusions: Our results suggest that genomic regions in postmenopausal African-American women contribute to variance in BMD and fat mass existence and warrant further study.

Original languageEnglish (US)
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number4
DOIs
StatePublished - Apr 2013

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Photon Absorptiometry
Bone Density
Minerals
Bone
Fats
X rays
Phenotype
Genes
Genome
African Americans
Chromosomes
Pelvic Bones
Health Resources
Femur Neck
Women's Health
Body Composition
Ethnic Groups
Single Nucleotide Polymorphism
Adipose Tissue
Polymorphism

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Ochs-Balcom, H. M., Preus, L., Wactawski-Wende, J., Nie, J., Johnson, N. A., Zakharia, F., ... Sucheston, L. E. (2013). Association of DXA-derived bone mineral density and fat mass with african ancestry. Journal of Clinical Endocrinology and Metabolism, 98(4). https://doi.org/10.1210/jc.2012-3921

Association of DXA-derived bone mineral density and fat mass with african ancestry. / Ochs-Balcom, Heather M.; Preus, Leah; Wactawski-Wende, Jean; Nie, Jing; Johnson, Nicholas A.; Zakharia, Fouad; Tang, Hua; Carlson, Chris; Carty, Cara; Chen, Zhao; Hoffman, Thomas; Hutter, Carolyn M.; Jackson, Rebecca D.; Kaplan, Robert C.; Li, Li; Liu, Song; Neuhouser, Marian L.; Peters, Ulrike; Robbins, John; Seldin, Michael F.; Thornton, Timothy A.; Thompson, Cheryl L.; Kooperberg, Charles; Sucheston, Lara E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 4, 04.2013.

Research output: Contribution to journalArticle

Ochs-Balcom, HM, Preus, L, Wactawski-Wende, J, Nie, J, Johnson, NA, Zakharia, F, Tang, H, Carlson, C, Carty, C, Chen, Z, Hoffman, T, Hutter, CM, Jackson, RD, Kaplan, RC, Li, L, Liu, S, Neuhouser, ML, Peters, U, Robbins, J, Seldin, MF, Thornton, TA, Thompson, CL, Kooperberg, C & Sucheston, LE 2013, 'Association of DXA-derived bone mineral density and fat mass with african ancestry', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 4. https://doi.org/10.1210/jc.2012-3921
Ochs-Balcom, Heather M. ; Preus, Leah ; Wactawski-Wende, Jean ; Nie, Jing ; Johnson, Nicholas A. ; Zakharia, Fouad ; Tang, Hua ; Carlson, Chris ; Carty, Cara ; Chen, Zhao ; Hoffman, Thomas ; Hutter, Carolyn M. ; Jackson, Rebecca D. ; Kaplan, Robert C. ; Li, Li ; Liu, Song ; Neuhouser, Marian L. ; Peters, Ulrike ; Robbins, John ; Seldin, Michael F. ; Thornton, Timothy A. ; Thompson, Cheryl L. ; Kooperberg, Charles ; Sucheston, Lara E. / Association of DXA-derived bone mineral density and fat mass with african ancestry. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 4.
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abstract = "Context: Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups. Objective: We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry. Setting/Participants: We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available. Methods: We derived both global and local ancestry estimates for each individual from Affymetrix 6.0 data and analyzed the correlation of DXA phenotypes with global African ancestry. For each phenotype, we examined the association of local genetic ancestry (number of African ancestral alleles at each marker) and each DXA phenotype at 570 282 markers acrossthe genome in additive models with adjustment for important covariates. Results: We identified statistically significant correlations of whole-body fat mass, trunk fat mass, and all 6 measures of BMD with a proportion of African ancestry. Genome-wide (admixture) significance for femoral neck BMD was achieved across 2 regions -3.7 MB and 0.3 MB on chromosome 19q13; similarly, total hip and intertrochanter BMD were associated with local ancestry in these regions. Trunk fat was the most significant fat mass phenotype showing strong, but not genomewide significant associations on chromosome Xp22. Conclusions: Our results suggest that genomic regions in postmenopausal African-American women contribute to variance in BMD and fat mass existence and warrant further study.",
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T1 - Association of DXA-derived bone mineral density and fat mass with african ancestry

AU - Ochs-Balcom, Heather M.

AU - Preus, Leah

AU - Wactawski-Wende, Jean

AU - Nie, Jing

AU - Johnson, Nicholas A.

AU - Zakharia, Fouad

AU - Tang, Hua

AU - Carlson, Chris

AU - Carty, Cara

AU - Chen, Zhao

AU - Hoffman, Thomas

AU - Hutter, Carolyn M.

AU - Jackson, Rebecca D.

AU - Kaplan, Robert C.

AU - Li, Li

AU - Liu, Song

AU - Neuhouser, Marian L.

AU - Peters, Ulrike

AU - Robbins, John

AU - Seldin, Michael F.

AU - Thornton, Timothy A.

AU - Thompson, Cheryl L.

AU - Kooperberg, Charles

AU - Sucheston, Lara E.

PY - 2013/4

Y1 - 2013/4

N2 - Context: Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups. Objective: We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry. Setting/Participants: We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available. Methods: We derived both global and local ancestry estimates for each individual from Affymetrix 6.0 data and analyzed the correlation of DXA phenotypes with global African ancestry. For each phenotype, we examined the association of local genetic ancestry (number of African ancestral alleles at each marker) and each DXA phenotype at 570 282 markers acrossthe genome in additive models with adjustment for important covariates. Results: We identified statistically significant correlations of whole-body fat mass, trunk fat mass, and all 6 measures of BMD with a proportion of African ancestry. Genome-wide (admixture) significance for femoral neck BMD was achieved across 2 regions -3.7 MB and 0.3 MB on chromosome 19q13; similarly, total hip and intertrochanter BMD were associated with local ancestry in these regions. Trunk fat was the most significant fat mass phenotype showing strong, but not genomewide significant associations on chromosome Xp22. Conclusions: Our results suggest that genomic regions in postmenopausal African-American women contribute to variance in BMD and fat mass existence and warrant further study.

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