Association of body mass index with peripheral arterial disease in older adults

Joachim H. Ix, Mary L. Biggs, Jorge Kizer, Kenneth J. Mukamal, Luc Djousse, Susan J. Zieman, Ian H. De Boer, Tracy L. Nelson, Anne B. Newman, Michael H. Criqui, David S. Siscovick

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The authors hypothesized that the absence of cross-sectional associations of body mass index (BMI; weight (kg)/height (m) 2) with peripheral arterial disease (PAD) in prior studies may reflect lower weight among persons who smoke or have poor health status. They conducted an observational study among 5,419 noninstitutionalized residents of 4 US communities aged ≥65 years at baseline (1989-1990 or 1992-1993). Ankle brachial index was measured, and participants reported their history of PAD procedures. Participants were followed longitudinally for adjudicated incident PAD events. At baseline, mean BMI was 26.6 (standard deviation, 4.6), and 776 participants (14%) had prevalent PAD. During 13.2 (median) years of follow-up through June 30, 2007, 276 incident PAD events occurred. In cross-sectional analysis, each 5-unit increase in BMI was inversely associated with PAD (prevalence ratio (PR) = 0.92, 95% confidence interval (CI): 0.85, 1.00). However, among persons in good health who had never smoked, the direction of association was opposite (PR = 1.20, 95% CI: 0.94, 1.52). Similar results were observed between BMI calculated using weight at age 50 years and PAD prevalence (PR = 1.30, 95% CI: 1.11, 1.51) and between BMI at baseline and incident PAD events occurring during follow-up (hazard ratio = 1.32, 95% CI: 1.00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age.

Original languageEnglish (US)
Pages (from-to)1036-1043
Number of pages8
JournalAmerican Journal of Epidemiology
Volume174
Issue number9
DOIs
StatePublished - Nov 1 2011
Externally publishedYes

Fingerprint

Peripheral Arterial Disease
Body Mass Index
Confidence Intervals
Weights and Measures
Ankle Brachial Index
Health
Smoke
Health Status
Observational Studies
Comorbidity
Cross-Sectional Studies
Maintenance

Keywords

  • ankle brachial index
  • body mass index
  • cardiovascular diseases
  • peripheral arterial disease

ASJC Scopus subject areas

  • Epidemiology

Cite this

Ix, J. H., Biggs, M. L., Kizer, J., Mukamal, K. J., Djousse, L., Zieman, S. J., ... Siscovick, D. S. (2011). Association of body mass index with peripheral arterial disease in older adults. American Journal of Epidemiology, 174(9), 1036-1043. https://doi.org/10.1093/aje/kwr228

Association of body mass index with peripheral arterial disease in older adults. / Ix, Joachim H.; Biggs, Mary L.; Kizer, Jorge; Mukamal, Kenneth J.; Djousse, Luc; Zieman, Susan J.; De Boer, Ian H.; Nelson, Tracy L.; Newman, Anne B.; Criqui, Michael H.; Siscovick, David S.

In: American Journal of Epidemiology, Vol. 174, No. 9, 01.11.2011, p. 1036-1043.

Research output: Contribution to journalArticle

Ix, JH, Biggs, ML, Kizer, J, Mukamal, KJ, Djousse, L, Zieman, SJ, De Boer, IH, Nelson, TL, Newman, AB, Criqui, MH & Siscovick, DS 2011, 'Association of body mass index with peripheral arterial disease in older adults', American Journal of Epidemiology, vol. 174, no. 9, pp. 1036-1043. https://doi.org/10.1093/aje/kwr228
Ix JH, Biggs ML, Kizer J, Mukamal KJ, Djousse L, Zieman SJ et al. Association of body mass index with peripheral arterial disease in older adults. American Journal of Epidemiology. 2011 Nov 1;174(9):1036-1043. https://doi.org/10.1093/aje/kwr228
Ix, Joachim H. ; Biggs, Mary L. ; Kizer, Jorge ; Mukamal, Kenneth J. ; Djousse, Luc ; Zieman, Susan J. ; De Boer, Ian H. ; Nelson, Tracy L. ; Newman, Anne B. ; Criqui, Michael H. ; Siscovick, David S. / Association of body mass index with peripheral arterial disease in older adults. In: American Journal of Epidemiology. 2011 ; Vol. 174, No. 9. pp. 1036-1043.
@article{e9fdf2adde3e43b084f76f5008ebb1a5,
title = "Association of body mass index with peripheral arterial disease in older adults",
abstract = "The authors hypothesized that the absence of cross-sectional associations of body mass index (BMI; weight (kg)/height (m) 2) with peripheral arterial disease (PAD) in prior studies may reflect lower weight among persons who smoke or have poor health status. They conducted an observational study among 5,419 noninstitutionalized residents of 4 US communities aged ≥65 years at baseline (1989-1990 or 1992-1993). Ankle brachial index was measured, and participants reported their history of PAD procedures. Participants were followed longitudinally for adjudicated incident PAD events. At baseline, mean BMI was 26.6 (standard deviation, 4.6), and 776 participants (14{\%}) had prevalent PAD. During 13.2 (median) years of follow-up through June 30, 2007, 276 incident PAD events occurred. In cross-sectional analysis, each 5-unit increase in BMI was inversely associated with PAD (prevalence ratio (PR) = 0.92, 95{\%} confidence interval (CI): 0.85, 1.00). However, among persons in good health who had never smoked, the direction of association was opposite (PR = 1.20, 95{\%} CI: 0.94, 1.52). Similar results were observed between BMI calculated using weight at age 50 years and PAD prevalence (PR = 1.30, 95{\%} CI: 1.11, 1.51) and between BMI at baseline and incident PAD events occurring during follow-up (hazard ratio = 1.32, 95{\%} CI: 1.00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age.",
keywords = "ankle brachial index, body mass index, cardiovascular diseases, peripheral arterial disease",
author = "Ix, {Joachim H.} and Biggs, {Mary L.} and Jorge Kizer and Mukamal, {Kenneth J.} and Luc Djousse and Zieman, {Susan J.} and {De Boer}, {Ian H.} and Nelson, {Tracy L.} and Newman, {Anne B.} and Criqui, {Michael H.} and Siscovick, {David S.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1093/aje/kwr228",
language = "English (US)",
volume = "174",
pages = "1036--1043",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Association of body mass index with peripheral arterial disease in older adults

AU - Ix, Joachim H.

AU - Biggs, Mary L.

AU - Kizer, Jorge

AU - Mukamal, Kenneth J.

AU - Djousse, Luc

AU - Zieman, Susan J.

AU - De Boer, Ian H.

AU - Nelson, Tracy L.

AU - Newman, Anne B.

AU - Criqui, Michael H.

AU - Siscovick, David S.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - The authors hypothesized that the absence of cross-sectional associations of body mass index (BMI; weight (kg)/height (m) 2) with peripheral arterial disease (PAD) in prior studies may reflect lower weight among persons who smoke or have poor health status. They conducted an observational study among 5,419 noninstitutionalized residents of 4 US communities aged ≥65 years at baseline (1989-1990 or 1992-1993). Ankle brachial index was measured, and participants reported their history of PAD procedures. Participants were followed longitudinally for adjudicated incident PAD events. At baseline, mean BMI was 26.6 (standard deviation, 4.6), and 776 participants (14%) had prevalent PAD. During 13.2 (median) years of follow-up through June 30, 2007, 276 incident PAD events occurred. In cross-sectional analysis, each 5-unit increase in BMI was inversely associated with PAD (prevalence ratio (PR) = 0.92, 95% confidence interval (CI): 0.85, 1.00). However, among persons in good health who had never smoked, the direction of association was opposite (PR = 1.20, 95% CI: 0.94, 1.52). Similar results were observed between BMI calculated using weight at age 50 years and PAD prevalence (PR = 1.30, 95% CI: 1.11, 1.51) and between BMI at baseline and incident PAD events occurring during follow-up (hazard ratio = 1.32, 95% CI: 1.00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age.

AB - The authors hypothesized that the absence of cross-sectional associations of body mass index (BMI; weight (kg)/height (m) 2) with peripheral arterial disease (PAD) in prior studies may reflect lower weight among persons who smoke or have poor health status. They conducted an observational study among 5,419 noninstitutionalized residents of 4 US communities aged ≥65 years at baseline (1989-1990 or 1992-1993). Ankle brachial index was measured, and participants reported their history of PAD procedures. Participants were followed longitudinally for adjudicated incident PAD events. At baseline, mean BMI was 26.6 (standard deviation, 4.6), and 776 participants (14%) had prevalent PAD. During 13.2 (median) years of follow-up through June 30, 2007, 276 incident PAD events occurred. In cross-sectional analysis, each 5-unit increase in BMI was inversely associated with PAD (prevalence ratio (PR) = 0.92, 95% confidence interval (CI): 0.85, 1.00). However, among persons in good health who had never smoked, the direction of association was opposite (PR = 1.20, 95% CI: 0.94, 1.52). Similar results were observed between BMI calculated using weight at age 50 years and PAD prevalence (PR = 1.30, 95% CI: 1.11, 1.51) and between BMI at baseline and incident PAD events occurring during follow-up (hazard ratio = 1.32, 95% CI: 1.00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age.

KW - ankle brachial index

KW - body mass index

KW - cardiovascular diseases

KW - peripheral arterial disease

UR - http://www.scopus.com/inward/record.url?scp=80054908042&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054908042&partnerID=8YFLogxK

U2 - 10.1093/aje/kwr228

DO - 10.1093/aje/kwr228

M3 - Article

C2 - 21920948

AN - SCOPUS:80054908042

VL - 174

SP - 1036

EP - 1043

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 9

ER -