Association of Baseline Neuropsychological Function and Progression of Illness Over 4 Years in HIV-Seropositive Individuals

Charles H. Silberstein, Mary Alice O’dowd, Ellie E. Schoenbaum, Gerald H. Friedland, Patricia Chartock, Cheryl Feiner, F. Patrick Mckegney

Research output: Contribution to journalArticle

2 Scopus citations


The authors conducted a study to examine the association between neuropsychological markers of central nervous system impairment and systemic human immunodeficiency virus (HIV) disease progression in a sample of 64 HIV-positive asymptomatic patients who were followed for a median of 45.6 months. Patients with poorer baseline scores on the Haistead-Reitan Trail-Making A neuropsychological test developed HIV-related systemic symptoms earlier over the study period than patients with the higher scores on the same test (P < 0.05). Subclinical neuropsychological dysfunction in otherwise asymptomatic HIV-infected individuals may be a harbinger of progressive HIV-related immunologic dysfunction.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
Issue number6
Publication statusPublished - Jan 1 1993


ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

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