Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans

Ainie Soetanto, Robert S. Wilson, Konrad Talbot, Ashley Un, Julie A. Schneider, Mark Sobiesk, Jeremiah Kelly, Sue Leurgans, David A. Bennett, Steven E. Arnold

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Context: Chronic psychological distress has deleterious effects on many of the body's physiological systems. In experimental animal models, chronic stress leads to neuroanatomic changes in the hippocampus, in particular a decrease in the length and branching of dendrites as well as a decrease in the number of dendritic spines. Objectives: To examine whether analogous distress-related neuroanatomic changes occur in humans and whether such changes might also be related to cognitive dysfunction observed in older people who report greater psychological distress. Design: Postmortem study of brain tissues from participants of the Religious Orders Study, an ongoing population-based clinicopathological study of aging and cognition. Setting: The Rush University Religious Orders Study and the University of Pennsylvania Cellular and Molecular Neuropathology Program. Participants: Seventy-two deceased participants of the Religious Orders Study. Main Outcome Measures: Densities of microtubule- associated protein 2-immunolabeled dendrites and synaptopodin-immunolabeled dendritic spines in the CA3 subfield of the hippocampus, quantified using semiautomated image acquisition and analysis. Results: Higher levels of trait anxiety and longitudinal depression scores were associated with decreased densities of dendrites and spines in CA3. Dendrite and spine densities did not correlate with an index of global cognition or with densities of common age-related pathological changes. Conclusions: Regressive neuronal changes occur in humans who experience greater psychological distress. These changes are analogous to neuronal changes in animal models of chronic stress.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
JournalArchives of General Psychiatry
Volume67
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

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Microtubule-Associated Proteins
Dendrites
Spine
Anxiety
Depression
Dendritic Spines
Psychology
Cognition
Hippocampus
Animal Models
Outcome Assessment (Health Care)
Microtubules
Protein
Brain
Population
Religious Orders
Psychological Distress

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. / Soetanto, Ainie; Wilson, Robert S.; Talbot, Konrad; Un, Ashley; Schneider, Julie A.; Sobiesk, Mark; Kelly, Jeremiah; Leurgans, Sue; Bennett, David A.; Arnold, Steven E.

In: Archives of General Psychiatry, Vol. 67, No. 5, 01.05.2010, p. 448-457.

Research output: Contribution to journalArticle

Soetanto, Ainie ; Wilson, Robert S. ; Talbot, Konrad ; Un, Ashley ; Schneider, Julie A. ; Sobiesk, Mark ; Kelly, Jeremiah ; Leurgans, Sue ; Bennett, David A. ; Arnold, Steven E. / Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. In: Archives of General Psychiatry. 2010 ; Vol. 67, No. 5. pp. 448-457.
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