Association of anthropometric measures and hemostatic factors in postmenopausal women: A longitudinal study

G. C. Kabat, M. Heo, M. A. Allison, L. Hou, R. Nassir, O. Zaslavsky, T. E. Rohan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background and aims: Obesity has been associated with increased levels of hemostatic factors. However, few studies have compared change in different anthropometric measures of adiposity in relation to change in levels of hemostatic factors. Our aim was to examine prospectively the association of change in body mass index (BMI), waist-hip ratio (WHR), waist circumference (WC), and waist circumference-height ratio (WHtR) with change in markers of hemostasis in a population of postmenopausal women. Methods and results: A subsample of women in the Women's Health Initiative (WHI) cohort had fasting blood samples and anthropometric measurements obtained at multiple time points over 12.8 years of follow-up. Of these, we studied the 2593 women who were not in the intervention arm of any WHI clinical trial. Their blood samples were used to measure plasma fibrinogen, factor VII antigen activity, and factor VII concentration at baseline, and at years 1, 3, and 6. We conducted mixed-effects linear regression analyses to examine the longitudinal association between change in anthropometric factors and change in hemostatic factors, adjusting for a wide range of potential confounding factors. In longitudinal analyses using repeated measures, change in BMI, WC, and WHtR were all positively associated with change in all 3 hemostatic factors. Change in anthropometric variables was most strongly associated with change in fibrinogen. Conclusions: Our results suggest that an increase in adiposity over time is robustly associated with increased levels of hemostatic factors.Registration number of clinical trial: NCT00000611.

Original languageEnglish (US)
Pages (from-to)1120-1127
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • Anthropometric factors
  • Factor VII antigen activity
  • Factor VII concentration
  • Fibrinogen
  • Hemostatic factors
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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