Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population

Ming Qing Xu, Qing He Xing, Yong Lan Zheng, Sheng Li, Jian Jun Gao, Guang He, Ting Wei Guo, Guo Yin Feng, Feng Xu, Lin He

Research output: Contribution to journalArticle

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Abstract

Background: A number of studies have pointed to the involvement of AKT signaling pathways in the etiology of schizophrenia. The purpose of this study was to determine whether the AKT1 gene is involved in the etiology of schizophrenia and whether it affects therapeutic outcomes in the Chinese population. Method: Five single nucleotide polymorphisms (SNPs) were genotyped among 384 schizophrenic patients (DSM-IV criteria) and 384 healthy controls from the Chinese population. We systematically analyzed the association of the AKT1 gene with schizophrenia on the basis of sex, age at onset, therapeutic response to typical antipsychotics and atypical antipsychotics, and presence or absence of extrapyramidal syndrome. The study was conducted from May 2004 to June 2006. Results: We found a positive association of the G allele of the SNP marker rs3803300 with schizophrenia (p = .003), both in early-onset and late-onset subjects, and that a haplotype A-G-C-G-A constructed by the 5 SNPs showed significant association (p = .00004886). However, we found no relationship between any of the 5 SNP markers and therapeutic response to typical and atypical antipsychotics and chlorpromazine-induced extrapyramidal syndrome. Conclusions: Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome.

Original languageEnglish (US)
Pages (from-to)1358-1367
Number of pages10
JournalJournal of Clinical Psychiatry
Volume68
Issue number9
StatePublished - Sep 2007
Externally publishedYes

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Antipsychotic Agents
Schizophrenia
Single Nucleotide Polymorphism
Population
Genes
Chlorpromazine
Therapeutics
Age of Onset
Diagnostic and Statistical Manual of Mental Disorders
Haplotypes
Alleles

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Xu, M. Q., Xing, Q. H., Zheng, Y. L., Li, S., Gao, J. J., He, G., ... He, L. (2007). Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. Journal of Clinical Psychiatry, 68(9), 1358-1367.

Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. / Xu, Ming Qing; Xing, Qing He; Zheng, Yong Lan; Li, Sheng; Gao, Jian Jun; He, Guang; Guo, Ting Wei; Feng, Guo Yin; Xu, Feng; He, Lin.

In: Journal of Clinical Psychiatry, Vol. 68, No. 9, 09.2007, p. 1358-1367.

Research output: Contribution to journalArticle

Xu, MQ, Xing, QH, Zheng, YL, Li, S, Gao, JJ, He, G, Guo, TW, Feng, GY, Xu, F & He, L 2007, 'Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population', Journal of Clinical Psychiatry, vol. 68, no. 9, pp. 1358-1367.
Xu, Ming Qing ; Xing, Qing He ; Zheng, Yong Lan ; Li, Sheng ; Gao, Jian Jun ; He, Guang ; Guo, Ting Wei ; Feng, Guo Yin ; Xu, Feng ; He, Lin. / Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population. In: Journal of Clinical Psychiatry. 2007 ; Vol. 68, No. 9. pp. 1358-1367.
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