Association Between Statin Use and Endometrial Cancer Survival

Nicole S. Nevadunsky, Anne Van Arsdale, Howard D. Strickler, Lori A. Spoozak, Alyson Moadel, Gurpreet Kaur, Eugenia Girda, Gary L. Goldberg, Mark H. Einstein

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Objective: To evaluate the association of 3 hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor (statin) use and concordant polypharmacy with disease-specific survival from endometrial cancer. Methods: A retrospective cohort study was conducted of 985 endometrial cancer cases treated from January 1999 through December 2009 at a single institution. Disease-specific survival was estimated by Kaplan-Meier analyses. A Cox proportional hazards model was used to study factors associated with survival. All statistical tests were two-sided and performed using Stata. Results: At the time of analysis, 230 patients (22% of evaluable patients) died of disease and median follow-up was 3.28 years. Disease-specific survival was greater (179/220 [81%]) for women with endometrial cancer taking statin therapy at the time of diagnosis and staging compared with women not using statins (423/570 [74%]) (log rank test, P.03). This association persisted for the subgroup of patients with nonendometrioid endometrial tumors who were statin users (59/87 [68%]) compared with nonusers (93/193 [43%]) (log rank test, P.02). The relationship remained significant (hazard ratio 0.63, 95% confidence interval [CI] 0.40-0.99) after adjusting for age, clinical stage, radiation, and other factors. Further evaluation of polypharmacy showed an association between concurrent statin and aspirin use with an especially low disease-specific mortality (hazard ratio 0.25, 95% CI 0.09-0.70) relative to those who used neither. Conclusion: Statin and aspirin use was associated with improved survival from nonendometrioid endometrial cancer.

Original languageEnglish (US)
Pages (from-to)144-150
Number of pages7
JournalObstetrics and gynecology
Volume126
Issue number1
DOIs
StatePublished - Jul 23 2015

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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