@article{82e0d1e8494f4e5f879b91d4f00b02cc,
title = "Association between Sleep Disordered Breathing and Left Ventricular Function: A Cross-Sectional Analysis of the ECHO-SOL Ancillary Study",
abstract = "Background: Prior studies have found that sleep-disordered breathing (SDB) is common among those with left ventricular (LV) dysfunction and heart failure. Few epidemiological studies have examined this association, especially in US Hispanic/Latinos, who may be at elevated risk of SDB and heart failure. Methods: We examined associations between SDB and LV diastolic and systolic function using data from 1506 adults aged 18 to 64 years in the Hispanic Community Health Study/Study of Latinos ECHO-SOL Ancillary Study (2011-2014). Home sleep testing was used to measure the apnea-hypopnea index, a measure of SDB severity. Echocardiography was performed a median of 2.1 years later to quantify LV diastolic function, systolic function, and structure. Multivariable linear regression was used to model the association between apnea-hypopnea index and echocardiographic measures while accounting for the complex survey design, demographics, body mass, and time between sleep and echocardiographic measurements. Results: Each 10-unit increase in apnea-hypopnea index was associated with 0.2 (95% CI, 0.1-0.3) lower E′, 0.3 (0.1-0.5) greater E/E′ ratio, and 1.07-fold (1.03-1.11) higher prevalence of diastolic dysfunction as well as 1.3 (0.3-2.4) g/m2greater LV mass index. These associations persisted after adjustment for hypertension and diabetes mellitus. In contrast, no association was identified between SDB severity and subclinical markers of LV systolic function. Conclusions: Greater SDB severity was associated with LV hypertrophy and subclinical markers of LV diastolic dysfunction. These findings suggest SDB in Hispanic/Latino men and women may contribute to the burden of heart failure in this population.",
keywords = "echocardiography, epidemiology, heart failure, risk factors, sleep",
author = "Ogilvie, {Rachel P.} and Genuardi, {Michael V.} and Magnani, {Jared W.} and Susan Redline and Daviglus, {Martha L.} and Neomi Shah and Mayank Kansal and Jianwen Cai and Ramos, {Alberto R.} and Hurwitz, {Barry E.} and Sonia Ponce and Patel, {Sanjay R.} and Rodriguez, {Carlos J.}",
note = "Funding Information: The Hispanic Community Health Study/Study of Latinos is supported by contracts from the NHLBI to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following contribute to the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, and NIH Institution-Office of Dietary Supplements. ECHO-SOL (Echocardiographic Study of Latinos) is supported by NHLBI grant R01-HL104199 (to Dr Rodriguez). Additional support for this analysis from the NIH, grants HL083825 (Dr Genuardi), HL082610 (Dr Ogilvie), and HL127307 (Dr Patel).*%blankline%* Funding Information: Dr Redline has received grant funding through her institution from Jazz Pharmaceuticals. She also received consulting fees from Jazz Pharmaceuticals and Respicardia unrelated to this article. Dr Patel has received grant funding through his institution from Bayer Pharmaceuticals, Philips Respironics, and Respicardia. He has also received consulting fees from the American Academy of Sleep Medicine.Dr Ramos has received grant funding through his institution from Jazz Pharmaceuticals and Boehringer Ingelheim. The other authors report no conflicts. Funding Information: The Hispanic Community Health Study/Study of Latinos is supported by contracts from the NHLBI to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following contribute to the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, and NIH Institution-Office of Dietary Supplements. ECHO-SOL (Echocardiographic Study of Latinos) is supported by NHLBI grant R01-HL104199 (to Dr Rodriguez). Additional support for this analysis from the NIH, grants HL083825 (Dr Genuardi), HL082610 (Dr Ogilvie), and HL127307 (Dr Patel). Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved.",
year = "2020",
month = may,
day = "1",
doi = "10.1161/CIRCIMAGING.119.009074",
language = "English (US)",
volume = "13",
journal = "Circulation: Cardiovascular Imaging",
issn = "1941-9651",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}