Association between Pulmonary Fibrosis and Coronary Artery Disease

Jorge Kizer, David A. Zisman, Nancy P. Blumenthal, Robert M. Kotloff, Stephen E. Kimmel, Robert M. Strieter, Selim M. Arcasoy, Victor A. Ferrari, John Hansen-Flaschen

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background: Pulmonary fibrosis and atherosclerosis have many similarities at the histopathologic level. Moreover, fibrotic lung diseases exhibit systemic effects and have the potential to affect the vasculature beyond the lung. The existence of a relationship between the two, however, has not been studied. Methods: To investigate whether fibrotic lung disorders may predispose to atherosclerosis, we conducted a cross-sectional study of 630 patients referred for lung transplantation evaluation at a university hospital. We compared the prevalence of angiographic coronary artery disease (CAD) in patients with fibrotic vs nonfibrotic lung diseases. Results: Fibrotic lung diseases were associated with an increased prevalence of CAD compared with nonfibrotic diseases after adjustment for traditional risk factors (odds ratio, 2.18; 95% confidence interval, 1.17-4.06). The magnitude and significance of this association were maintained when only nongranulomatous fibrotic disease or its subset, idiopathic pulmonary fibrosis, was examined. The strength of the relationship between fibrotic disorders and CAD increased when multivessel disease was analyzed (odds ratio, 4.16; 95% confidence interval, 1.46-11.9). No significant association was detected for granulomatous fibrotic disorders (odds ratio, 1.56; 95% confidence interval, 0.47-5.16; P=.47), although this subgroup had fewer cases of CAD for analysis. Conclusions: These findings support an association between fibrotic lung disorders and CAD. Further research is necessary to confirm this relationship and to explore the pathologic processes underlying, and potentially linking, these 2 conditions.

Original languageEnglish (US)
Pages (from-to)551-556
Number of pages6
JournalArchives of Internal Medicine
Volume164
Issue number5
DOIs
StatePublished - Mar 8 2004
Externally publishedYes

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Pulmonary Fibrosis
Pulmonary Artery
Coronary Artery Disease
Lung Diseases
Odds Ratio
Confidence Intervals
Lung
Atherosclerosis
Idiopathic Pulmonary Fibrosis
Lung Transplantation
Pathologic Processes
Cross-Sectional Studies
Research

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Kizer, J., Zisman, D. A., Blumenthal, N. P., Kotloff, R. M., Kimmel, S. E., Strieter, R. M., ... Hansen-Flaschen, J. (2004). Association between Pulmonary Fibrosis and Coronary Artery Disease. Archives of Internal Medicine, 164(5), 551-556. https://doi.org/10.1001/archinte.164.5.551

Association between Pulmonary Fibrosis and Coronary Artery Disease. / Kizer, Jorge; Zisman, David A.; Blumenthal, Nancy P.; Kotloff, Robert M.; Kimmel, Stephen E.; Strieter, Robert M.; Arcasoy, Selim M.; Ferrari, Victor A.; Hansen-Flaschen, John.

In: Archives of Internal Medicine, Vol. 164, No. 5, 08.03.2004, p. 551-556.

Research output: Contribution to journalArticle

Kizer, J, Zisman, DA, Blumenthal, NP, Kotloff, RM, Kimmel, SE, Strieter, RM, Arcasoy, SM, Ferrari, VA & Hansen-Flaschen, J 2004, 'Association between Pulmonary Fibrosis and Coronary Artery Disease', Archives of Internal Medicine, vol. 164, no. 5, pp. 551-556. https://doi.org/10.1001/archinte.164.5.551
Kizer J, Zisman DA, Blumenthal NP, Kotloff RM, Kimmel SE, Strieter RM et al. Association between Pulmonary Fibrosis and Coronary Artery Disease. Archives of Internal Medicine. 2004 Mar 8;164(5):551-556. https://doi.org/10.1001/archinte.164.5.551
Kizer, Jorge ; Zisman, David A. ; Blumenthal, Nancy P. ; Kotloff, Robert M. ; Kimmel, Stephen E. ; Strieter, Robert M. ; Arcasoy, Selim M. ; Ferrari, Victor A. ; Hansen-Flaschen, John. / Association between Pulmonary Fibrosis and Coronary Artery Disease. In: Archives of Internal Medicine. 2004 ; Vol. 164, No. 5. pp. 551-556.
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