TY - JOUR
T1 - Association between prolonged P wave duration and left atrial scarring in patients with paroxysmal atrial fibrillation
AU - Chen, Qiong
AU - Mohanty, Sanghamitra
AU - Trivedi, Chintan
AU - Gianni, Carola
AU - Della Rocca, Domenico G.
AU - Canpolat, Ugur
AU - Burkhardt, John David
AU - Sanchez, Javier E.
AU - Hranitzky, Patrick
AU - Gallinghouse, Gerald Joseph
AU - Al-Ahmad, Amin
AU - Horton, Rodney
AU - Di Biase, Luigi
AU - Natale, Andrea
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: We evaluated the association of P wave duration (PWD) with left atrial scar (LAS) in patients with paroxysmal atrial fibrillation (PAF). Methods: Consecutive patients with PAF undergoing their first catheter ablation were screened and only those in sinus rhythm at baseline were included in the analysis. A standard 12-lead electrocardiogram (ECG) was performed in all and three-dimensional voltage mapping of the left atrium was generated for identification of low-voltage areas (≤0.2 mV) before the procedure. Results: In total, 411 patients with PAF were included in this study of which 181 had LASs (scar group), while 230 had no scar (nonscar group). In the scar group, patients were older (65.5 ± 8.8 vs 59.7 ± 11.7 years; P <.001), the proportion of female was higher (47.5% vs 37.4%; P =.04) and left atrial (LA) diameter (4.1 ± 0.6 vs 3.9 ± 0.6 cm; P <.001) was larger compared with the nonscar group. There was no significant difference in terms of hypertension, sleep apnea, and diabetes between the two groups. When comparing ECG characteristics between the two groups, PWD was significantly longer in the scar group (122.9 ± 18.5 and 116.9 ± 28.0 ms; P =.01). A multivariate analysis was performed, after adjustment of age, sex, LA diameter, PWD ≥ 120 ms was found to be an independent predictor of LA scarring (OR: 1.69, p-value: 0.02). Conclusion: In the current series, prolonged PWD was found to be independently associated with LA scarring in PAF, even after adjustment for age, sex, and LA diameter.
AB - Background: We evaluated the association of P wave duration (PWD) with left atrial scar (LAS) in patients with paroxysmal atrial fibrillation (PAF). Methods: Consecutive patients with PAF undergoing their first catheter ablation were screened and only those in sinus rhythm at baseline were included in the analysis. A standard 12-lead electrocardiogram (ECG) was performed in all and three-dimensional voltage mapping of the left atrium was generated for identification of low-voltage areas (≤0.2 mV) before the procedure. Results: In total, 411 patients with PAF were included in this study of which 181 had LASs (scar group), while 230 had no scar (nonscar group). In the scar group, patients were older (65.5 ± 8.8 vs 59.7 ± 11.7 years; P <.001), the proportion of female was higher (47.5% vs 37.4%; P =.04) and left atrial (LA) diameter (4.1 ± 0.6 vs 3.9 ± 0.6 cm; P <.001) was larger compared with the nonscar group. There was no significant difference in terms of hypertension, sleep apnea, and diabetes between the two groups. When comparing ECG characteristics between the two groups, PWD was significantly longer in the scar group (122.9 ± 18.5 and 116.9 ± 28.0 ms; P =.01). A multivariate analysis was performed, after adjustment of age, sex, LA diameter, PWD ≥ 120 ms was found to be an independent predictor of LA scarring (OR: 1.69, p-value: 0.02). Conclusion: In the current series, prolonged PWD was found to be independently associated with LA scarring in PAF, even after adjustment for age, sex, and LA diameter.
KW - LA scar
KW - P wave duration
KW - paroxysmal AF
KW - recurrence
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U2 - 10.1111/jce.14070
DO - 10.1111/jce.14070
M3 - Article
C2 - 31310407
AN - SCOPUS:85073082100
SN - 1045-3873
VL - 30
SP - 1811
EP - 1818
JO - Journal of Cardiovascular Electrophysiology
JF - Journal of Cardiovascular Electrophysiology
IS - 10
ER -
