Association between neutrophil–lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma

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Abstract

Background: Patients with lower socioeconomic status (SES), ethnic minorities and elevated neutrophil–lymphocyte ratio (NLR) have been suggested to have worse outcomes in hepatocellular carcinoma (HCC). However, how changes in NLR after intervention relate to survival has not been elucidated. Objectives: We evaluated the association of NLR with overall survival (OS) and progression-free survival (PFS) in a large institutional cohort of HCC. Methods: We reviewed all patients diagnosed with HCC between 2005–2016. The association between elevated NLR (> 4) and survival was examined with univariable and multivariable Cox regression. Results: We identified 991 patients diagnosed with HCC. Lower SES and Hispanic and non-Hispanic Black ethnicity were significantly associated with lower NLR (p = 0.015 and 0.019, respectively). Elevated NLR, but not SES or ethnicity, was an independent predictor of worse OS (HR = 1.66, p < 0.001) and PFS (HR = 1.25, p = 0.032). The median OS in patients with elevated NLR was 8 months, compared to 42 months in patients with normal NLR. Patients with elevated NLR unresponsive to treatment and those with NLR that became elevated after treatment had significantly worse 3-year OS (47% and 44%, respectively), compared to patients whose NLR remained normal or normalized after treatment (72% and 80%, respectively; p < 0.01). Conclusions: Our study showed that elevated NLR, but not SES or ethnicity, is an independent prognostic marker for OS and PFS in patients with HCC. NLR trends following intervention were highly predictive of outcome. NLR is easy to obtain and would provide valuable information to clinicians in evaluating prognosis and monitoring response after procedures.

Original languageEnglish (US)
JournalHepatology International
DOIs
StateAccepted/In press - Jan 1 2019

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Social Class
Hepatocellular Carcinoma
Survival
Disease-Free Survival
Hispanic Americans
Therapeutics

Keywords

  • Ethnicity
  • Hepatocellular carcinoma
  • Neutrophil-to-lymphocyte ratio
  • Prognosis
  • Socioeconomic status

ASJC Scopus subject areas

  • Hepatology

Cite this

@article{eada8c059c1d4d8baf4dbb6d525ea506,
title = "Association between neutrophil–lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma",
abstract = "Background: Patients with lower socioeconomic status (SES), ethnic minorities and elevated neutrophil–lymphocyte ratio (NLR) have been suggested to have worse outcomes in hepatocellular carcinoma (HCC). However, how changes in NLR after intervention relate to survival has not been elucidated. Objectives: We evaluated the association of NLR with overall survival (OS) and progression-free survival (PFS) in a large institutional cohort of HCC. Methods: We reviewed all patients diagnosed with HCC between 2005–2016. The association between elevated NLR (> 4) and survival was examined with univariable and multivariable Cox regression. Results: We identified 991 patients diagnosed with HCC. Lower SES and Hispanic and non-Hispanic Black ethnicity were significantly associated with lower NLR (p = 0.015 and 0.019, respectively). Elevated NLR, but not SES or ethnicity, was an independent predictor of worse OS (HR = 1.66, p < 0.001) and PFS (HR = 1.25, p = 0.032). The median OS in patients with elevated NLR was 8 months, compared to 42 months in patients with normal NLR. Patients with elevated NLR unresponsive to treatment and those with NLR that became elevated after treatment had significantly worse 3-year OS (47{\%} and 44{\%}, respectively), compared to patients whose NLR remained normal or normalized after treatment (72{\%} and 80{\%}, respectively; p < 0.01). Conclusions: Our study showed that elevated NLR, but not SES or ethnicity, is an independent prognostic marker for OS and PFS in patients with HCC. NLR trends following intervention were highly predictive of outcome. NLR is easy to obtain and would provide valuable information to clinicians in evaluating prognosis and monitoring response after procedures.",
keywords = "Ethnicity, Hepatocellular carcinoma, Neutrophil-to-lymphocyte ratio, Prognosis, Socioeconomic status",
author = "Yifei Zhang and Brodin, {Nils P.} and Nitin Ohri and Santiago Thibaud and Andreas Kaubisch and Milan Kinkhabwala and Garg, {Madhur K.} and Chandan Guha and Rafi Kabarriti",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s12072-019-09965-0",
language = "English (US)",
journal = "Hepatology International",
issn = "1936-0533",
publisher = "Springer New York",

}

TY - JOUR

T1 - Association between neutrophil–lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma

AU - Zhang, Yifei

AU - Brodin, Nils P.

AU - Ohri, Nitin

AU - Thibaud, Santiago

AU - Kaubisch, Andreas

AU - Kinkhabwala, Milan

AU - Garg, Madhur K.

AU - Guha, Chandan

AU - Kabarriti, Rafi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Patients with lower socioeconomic status (SES), ethnic minorities and elevated neutrophil–lymphocyte ratio (NLR) have been suggested to have worse outcomes in hepatocellular carcinoma (HCC). However, how changes in NLR after intervention relate to survival has not been elucidated. Objectives: We evaluated the association of NLR with overall survival (OS) and progression-free survival (PFS) in a large institutional cohort of HCC. Methods: We reviewed all patients diagnosed with HCC between 2005–2016. The association between elevated NLR (> 4) and survival was examined with univariable and multivariable Cox regression. Results: We identified 991 patients diagnosed with HCC. Lower SES and Hispanic and non-Hispanic Black ethnicity were significantly associated with lower NLR (p = 0.015 and 0.019, respectively). Elevated NLR, but not SES or ethnicity, was an independent predictor of worse OS (HR = 1.66, p < 0.001) and PFS (HR = 1.25, p = 0.032). The median OS in patients with elevated NLR was 8 months, compared to 42 months in patients with normal NLR. Patients with elevated NLR unresponsive to treatment and those with NLR that became elevated after treatment had significantly worse 3-year OS (47% and 44%, respectively), compared to patients whose NLR remained normal or normalized after treatment (72% and 80%, respectively; p < 0.01). Conclusions: Our study showed that elevated NLR, but not SES or ethnicity, is an independent prognostic marker for OS and PFS in patients with HCC. NLR trends following intervention were highly predictive of outcome. NLR is easy to obtain and would provide valuable information to clinicians in evaluating prognosis and monitoring response after procedures.

AB - Background: Patients with lower socioeconomic status (SES), ethnic minorities and elevated neutrophil–lymphocyte ratio (NLR) have been suggested to have worse outcomes in hepatocellular carcinoma (HCC). However, how changes in NLR after intervention relate to survival has not been elucidated. Objectives: We evaluated the association of NLR with overall survival (OS) and progression-free survival (PFS) in a large institutional cohort of HCC. Methods: We reviewed all patients diagnosed with HCC between 2005–2016. The association between elevated NLR (> 4) and survival was examined with univariable and multivariable Cox regression. Results: We identified 991 patients diagnosed with HCC. Lower SES and Hispanic and non-Hispanic Black ethnicity were significantly associated with lower NLR (p = 0.015 and 0.019, respectively). Elevated NLR, but not SES or ethnicity, was an independent predictor of worse OS (HR = 1.66, p < 0.001) and PFS (HR = 1.25, p = 0.032). The median OS in patients with elevated NLR was 8 months, compared to 42 months in patients with normal NLR. Patients with elevated NLR unresponsive to treatment and those with NLR that became elevated after treatment had significantly worse 3-year OS (47% and 44%, respectively), compared to patients whose NLR remained normal or normalized after treatment (72% and 80%, respectively; p < 0.01). Conclusions: Our study showed that elevated NLR, but not SES or ethnicity, is an independent prognostic marker for OS and PFS in patients with HCC. NLR trends following intervention were highly predictive of outcome. NLR is easy to obtain and would provide valuable information to clinicians in evaluating prognosis and monitoring response after procedures.

KW - Ethnicity

KW - Hepatocellular carcinoma

KW - Neutrophil-to-lymphocyte ratio

KW - Prognosis

KW - Socioeconomic status

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U2 - 10.1007/s12072-019-09965-0

DO - 10.1007/s12072-019-09965-0

M3 - Article

JO - Hepatology International

JF - Hepatology International

SN - 1936-0533

ER -