Association between human immunodeficiency virus infection and stiffness of the common carotid artery

Eric C. Seaberg, Lorie Benning, A. Richey Sharrett, Jason M. Lazar, Howard N. Hodis, Wendy J. MacK, Mark J. Siedner, John P. Phair, Lawrence A. Kingsley, Robert C. Kaplan

Research output: Contribution to journalArticle

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Abstract

Background And Purpose-: Individuals with human immunodeficiency virus (HIV) who use highly active antiretroviral therapy (HAART) may have an increased risk for cardiovascular-related events, although the underlying mechanism remains unclear. We tested the hypothesis that carotid arterial stiffness was higher among persons using HAART compared to HAART-naïve and HIV-uninfected persons. Methods-: Between 2004 and 2006, we performed high-resolution B-mode ultrasound on 2789 HIV-infected and HIV-uninfected participants of the Women's Interagency HIV Study (1865 women) and the Multicenter AIDS Cohort Study (924 men) and determined carotid arterial distensibility, which is a direct measure of carotid arterial stiffness. We used generalized estimating equations to evaluate the association between distensibility and HIV infection, CD4 cell count, and exposure to HAART adjusted for demographic, behavioral, and clinical characteristics. Results-: In multivariable analysis, distensibility was 4.3% lower (95% confidence interval, -7.4% to -1.1%) among HIV-infected vs uninfected participants. Among HIV-infected participants with <200 CD4+ cells, distensibility was 10.5% lower (95% confidence interval, -14.5% to -6.2%) than that among HIV-uninfected participants, and this effect did not differ significantly by cohort or race. Concurrent HAART use was independently associated with lower distensibility among Multicenter AIDS Cohort Study participants but not among Women's Interagency HIV Study participants. Conclusions-: Our finding that advanced HIV-related immunosuppression was associated with increased carotid arterial stiffness independent from the effects of traditional atherosclerosis risk factors suggests that the etiologic mechanism underlying reports of an increased cardiovascular disease risk among HIV-infected individuals might involve HIV-related immunosuppression leading to vascular dysfunction and arterial stiffening.

Original languageEnglish (US)
Pages (from-to)2163-2170
Number of pages8
JournalStroke
Volume41
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Common Carotid Artery
Virus Diseases
HIV
Highly Active Antiretroviral Therapy
Vascular Stiffness
Immunosuppression
Acquired Immunodeficiency Syndrome
Cohort Studies
Confidence Intervals
CD4 Lymphocyte Count
Blood Vessels
Atherosclerosis
Cardiovascular Diseases

Keywords

  • atherosclerosis
  • cardiovascular disease
  • carotid arteries
  • epidemiology
  • HIV

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Medicine(all)

Cite this

Seaberg, E. C., Benning, L., Sharrett, A. R., Lazar, J. M., Hodis, H. N., MacK, W. J., ... Kaplan, R. C. (2010). Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Stroke, 41(10), 2163-2170. https://doi.org/10.1161/STROKEAHA.110.583856

Association between human immunodeficiency virus infection and stiffness of the common carotid artery. / Seaberg, Eric C.; Benning, Lorie; Sharrett, A. Richey; Lazar, Jason M.; Hodis, Howard N.; MacK, Wendy J.; Siedner, Mark J.; Phair, John P.; Kingsley, Lawrence A.; Kaplan, Robert C.

In: Stroke, Vol. 41, No. 10, 10.2010, p. 2163-2170.

Research output: Contribution to journalArticle

Seaberg, EC, Benning, L, Sharrett, AR, Lazar, JM, Hodis, HN, MacK, WJ, Siedner, MJ, Phair, JP, Kingsley, LA & Kaplan, RC 2010, 'Association between human immunodeficiency virus infection and stiffness of the common carotid artery', Stroke, vol. 41, no. 10, pp. 2163-2170. https://doi.org/10.1161/STROKEAHA.110.583856
Seaberg EC, Benning L, Sharrett AR, Lazar JM, Hodis HN, MacK WJ et al. Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Stroke. 2010 Oct;41(10):2163-2170. https://doi.org/10.1161/STROKEAHA.110.583856
Seaberg, Eric C. ; Benning, Lorie ; Sharrett, A. Richey ; Lazar, Jason M. ; Hodis, Howard N. ; MacK, Wendy J. ; Siedner, Mark J. ; Phair, John P. ; Kingsley, Lawrence A. ; Kaplan, Robert C. / Association between human immunodeficiency virus infection and stiffness of the common carotid artery. In: Stroke. 2010 ; Vol. 41, No. 10. pp. 2163-2170.
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abstract = "Background And Purpose-: Individuals with human immunodeficiency virus (HIV) who use highly active antiretroviral therapy (HAART) may have an increased risk for cardiovascular-related events, although the underlying mechanism remains unclear. We tested the hypothesis that carotid arterial stiffness was higher among persons using HAART compared to HAART-na{\"i}ve and HIV-uninfected persons. Methods-: Between 2004 and 2006, we performed high-resolution B-mode ultrasound on 2789 HIV-infected and HIV-uninfected participants of the Women's Interagency HIV Study (1865 women) and the Multicenter AIDS Cohort Study (924 men) and determined carotid arterial distensibility, which is a direct measure of carotid arterial stiffness. We used generalized estimating equations to evaluate the association between distensibility and HIV infection, CD4 cell count, and exposure to HAART adjusted for demographic, behavioral, and clinical characteristics. Results-: In multivariable analysis, distensibility was 4.3{\%} lower (95{\%} confidence interval, -7.4{\%} to -1.1{\%}) among HIV-infected vs uninfected participants. Among HIV-infected participants with <200 CD4+ cells, distensibility was 10.5{\%} lower (95{\%} confidence interval, -14.5{\%} to -6.2{\%}) than that among HIV-uninfected participants, and this effect did not differ significantly by cohort or race. Concurrent HAART use was independently associated with lower distensibility among Multicenter AIDS Cohort Study participants but not among Women's Interagency HIV Study participants. Conclusions-: Our finding that advanced HIV-related immunosuppression was associated with increased carotid arterial stiffness independent from the effects of traditional atherosclerosis risk factors suggests that the etiologic mechanism underlying reports of an increased cardiovascular disease risk among HIV-infected individuals might involve HIV-related immunosuppression leading to vascular dysfunction and arterial stiffening.",
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AU - Hodis, Howard N.

AU - MacK, Wendy J.

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AB - Background And Purpose-: Individuals with human immunodeficiency virus (HIV) who use highly active antiretroviral therapy (HAART) may have an increased risk for cardiovascular-related events, although the underlying mechanism remains unclear. We tested the hypothesis that carotid arterial stiffness was higher among persons using HAART compared to HAART-naïve and HIV-uninfected persons. Methods-: Between 2004 and 2006, we performed high-resolution B-mode ultrasound on 2789 HIV-infected and HIV-uninfected participants of the Women's Interagency HIV Study (1865 women) and the Multicenter AIDS Cohort Study (924 men) and determined carotid arterial distensibility, which is a direct measure of carotid arterial stiffness. We used generalized estimating equations to evaluate the association between distensibility and HIV infection, CD4 cell count, and exposure to HAART adjusted for demographic, behavioral, and clinical characteristics. Results-: In multivariable analysis, distensibility was 4.3% lower (95% confidence interval, -7.4% to -1.1%) among HIV-infected vs uninfected participants. Among HIV-infected participants with <200 CD4+ cells, distensibility was 10.5% lower (95% confidence interval, -14.5% to -6.2%) than that among HIV-uninfected participants, and this effect did not differ significantly by cohort or race. Concurrent HAART use was independently associated with lower distensibility among Multicenter AIDS Cohort Study participants but not among Women's Interagency HIV Study participants. Conclusions-: Our finding that advanced HIV-related immunosuppression was associated with increased carotid arterial stiffness independent from the effects of traditional atherosclerosis risk factors suggests that the etiologic mechanism underlying reports of an increased cardiovascular disease risk among HIV-infected individuals might involve HIV-related immunosuppression leading to vascular dysfunction and arterial stiffening.

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