Association between genetic variations of vascular endothelial growth factor receptor 2 and glioma in the Chinese Han population

Hongyan Chen, Weimin Wang, Zhao Xingjie, Xiao Song, Weiwei Fan, Zhou Keke, Gong Chen, Yao Zhao, Ying Mao, Daru Lu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Tumor angiogenesis, which is an important step in the development of cancer, is directly regulated by vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we examined the association of five potentially functional VEGFR-2 polymorphisms with glioma risk in a Chinese Han population. Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P00.006, 0.005, and 0.012, respectively). Both haplotype and diplotype analyses consistently revealed that subjects carrying two copies of the haplotype "CGT" had a 42% reduced glioma risk compared with their respective noncarriers. Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
JournalJournal of Molecular Neuroscience
Volume47
Issue number3
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Angiogenesis
  • Genetic susceptibility
  • Glioma
  • Haplotype
  • Polymorphism
  • VEGFR-2

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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