TY - JOUR
T1 - Association between dietary zinc intake and abdominal aortic calcification in US adults
AU - Chen, Wei
AU - Eisenberg, Ruth
AU - Mowrey, Wenzhu B.
AU - Wylie-Rosett, Judith
AU - Abramowitz, Matthew K.
AU - Bushinsky, David A.
AU - Melamed, Michal L.
N1 - Publisher Copyright:
© 2020 Oxford University Press. All rights reserved.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Background. In animal studies, zinc supplementation inhibited phosphate-induced arterial calcification. We tested the hypothesis that higher intake of dietary zinc was associated with lower abdominal aortic calcification (AAC) among adults in the USA. We also explored the associations of AAC with supplemental zinc intake, total zinc intake and serum zinc level. Methods. We performed cross-sectional analyses of 2535 participants from the National Health and Nutrition Examination Survey 2013 14. Dietary and supplemental zinc intakes were obtained from two 24-h dietary recall interviews. Total zinc intake was the sum of dietary and supplemental zinc. AAC was measured using dual-energy X-ray absorptiometry in adults 40 years of age and quantified using the Kauppila score system. AAC scores were categorized into three groups: no AAC (AAC 0, reference group), mild moderate (AAC0 6) and severe AAC (AAC6). Results. Dietary zinc intake (mean 6 SE) was 10.560.1mg/ day; 28% had AAC (20% mild moderate and 8% severe), 17% had diabetes mellitus and 51% had hypertension. Higher intake of dietary zinc was associated with lower odds of having severe AAC. Per 1 mg/day higher intake of dietary zinc, the odds of having severe AAC were 8% lower [adjusted odds ratio 0.92 (95% confidence interval 0.86 0.98), P 0.01] compared with those without AAC, after adjusting for demographics, comorbidities and laboratory measurements. Supplemental zinc intake, total zinc intake and serum zinc level were not associated with AAC. Conclusions. Higher intake of dietary zinc was independently associated with lower odds of having severe AAC among noninstitutionalized US adults.
AB - Background. In animal studies, zinc supplementation inhibited phosphate-induced arterial calcification. We tested the hypothesis that higher intake of dietary zinc was associated with lower abdominal aortic calcification (AAC) among adults in the USA. We also explored the associations of AAC with supplemental zinc intake, total zinc intake and serum zinc level. Methods. We performed cross-sectional analyses of 2535 participants from the National Health and Nutrition Examination Survey 2013 14. Dietary and supplemental zinc intakes were obtained from two 24-h dietary recall interviews. Total zinc intake was the sum of dietary and supplemental zinc. AAC was measured using dual-energy X-ray absorptiometry in adults 40 years of age and quantified using the Kauppila score system. AAC scores were categorized into three groups: no AAC (AAC 0, reference group), mild moderate (AAC0 6) and severe AAC (AAC6). Results. Dietary zinc intake (mean 6 SE) was 10.560.1mg/ day; 28% had AAC (20% mild moderate and 8% severe), 17% had diabetes mellitus and 51% had hypertension. Higher intake of dietary zinc was associated with lower odds of having severe AAC. Per 1 mg/day higher intake of dietary zinc, the odds of having severe AAC were 8% lower [adjusted odds ratio 0.92 (95% confidence interval 0.86 0.98), P 0.01] compared with those without AAC, after adjusting for demographics, comorbidities and laboratory measurements. Supplemental zinc intake, total zinc intake and serum zinc level were not associated with AAC. Conclusions. Higher intake of dietary zinc was independently associated with lower odds of having severe AAC among noninstitutionalized US adults.
KW - cardiovascular disease
KW - mineral metabolism
KW - nutrition
KW - vascular calcification
KW - zinc
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U2 - 10.1093/ndt/gfz134
DO - 10.1093/ndt/gfz134
M3 - Article
C2 - 31298287
AN - SCOPUS:85082146167
VL - 35
SP - 1171
EP - 1178
JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
SN - 0931-0509
IS - 7
ER -