Association between cumulative psychosocial risk and cervical human papillomavirus infection among female adolescents in a free vaccination program

Lourdes Oriana Linares, Shankar Viswanathan, Angela Diaz, Anne Nucci-Sack, Howard Strickler, Ken Peake, Jocelyn Weiss, Robert D. Burk, Nicolas F. Schlecht

Research output: Contribution to journalArticle

Abstract

Objective: This study investigated the association of cervical human papillomavirus (HPV) infection with cumulative psychosocial risk reflecting family disadvantage, psychological distress, and unhealthy lifestyle. Methods: The sample (N 5 745) comprised sexually active female adolescent patients (12-19 yr), primarily ethnic minorities, enrolled in a free HPV vaccination program. Subjects completed questionnaires and provided cervical swabs for HPV DNA testing. Unweighted and weighted principal component analyses for categorical data were used to derive multisystemic psychosocial risk indices using 9 indicators: low socioeconomic status, lack of adult involvement, not attending high school/college, history of treatment for depression/anxiety, antisocial/delinquent behavior, number of recent sexual partners, use of alcohol, use of drugs, and dependency risk for alcohol/drugs. The association between cervical HPV (any type, high-risk types, vaccine types) assayed by polymerase chain reaction and self-reported number of psychosocial risk indicators was estimated using multivariable logistic regression. Results: Subjects had a median of 3 psychosocial risk indicators. Multiple logistic regression analyses showed associations with unweighted and weighted number of psychosocial indicators for HPV any type (adjusted odds ratio [aOR] 5 1.1; 95% confidence interval [CI], 1.0-1.2), with the strongest associations between weighted drug/alcohol use, drug/alcohol dependency risk, and antisocial/delinquent behavior and detection of HPV vaccine types (aOR 5 1.5; 95% CI, 1.1-2.0) independent of number of recent sexual partners and vaccine dose (0-3). Conclusion: Increased HPV infections including HPV vaccine types were associated with greater number of psychosocial risk indicators even after controlling for demographics, sexual behavior, history of chlamydia, and vaccine dose.

Original languageEnglish (US)
Pages (from-to)620-627
Number of pages8
JournalJournal of Developmental and Behavioral Pediatrics
Volume36
Issue number8
StatePublished - 2015

Fingerprint

Papillomavirus Infections
Vaccination
Alcohols
Papillomavirus Vaccines
Vaccines
Sexual Partners
Pharmaceutical Preparations
Logistic Models
Odds Ratio
Confidence Intervals
Chlamydia
Principal Component Analysis
Social Class
Sexual Behavior
Life Style
Anxiety
Regression Analysis
Demography
Depression
Psychology

Keywords

  • Adolescent health
  • Alcohol
  • Drugs
  • HPV
  • Human papillomavirus
  • Psychosocial risk
  • Sexual activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Association between cumulative psychosocial risk and cervical human papillomavirus infection among female adolescents in a free vaccination program. / Linares, Lourdes Oriana; Viswanathan, Shankar; Diaz, Angela; Nucci-Sack, Anne; Strickler, Howard; Peake, Ken; Weiss, Jocelyn; Burk, Robert D.; Schlecht, Nicolas F.

In: Journal of Developmental and Behavioral Pediatrics, Vol. 36, No. 8, 2015, p. 620-627.

Research output: Contribution to journalArticle

@article{dbf67bd2816e4532bc2dbd5603475b67,
title = "Association between cumulative psychosocial risk and cervical human papillomavirus infection among female adolescents in a free vaccination program",
abstract = "Objective: This study investigated the association of cervical human papillomavirus (HPV) infection with cumulative psychosocial risk reflecting family disadvantage, psychological distress, and unhealthy lifestyle. Methods: The sample (N 5 745) comprised sexually active female adolescent patients (12-19 yr), primarily ethnic minorities, enrolled in a free HPV vaccination program. Subjects completed questionnaires and provided cervical swabs for HPV DNA testing. Unweighted and weighted principal component analyses for categorical data were used to derive multisystemic psychosocial risk indices using 9 indicators: low socioeconomic status, lack of adult involvement, not attending high school/college, history of treatment for depression/anxiety, antisocial/delinquent behavior, number of recent sexual partners, use of alcohol, use of drugs, and dependency risk for alcohol/drugs. The association between cervical HPV (any type, high-risk types, vaccine types) assayed by polymerase chain reaction and self-reported number of psychosocial risk indicators was estimated using multivariable logistic regression. Results: Subjects had a median of 3 psychosocial risk indicators. Multiple logistic regression analyses showed associations with unweighted and weighted number of psychosocial indicators for HPV any type (adjusted odds ratio [aOR] 5 1.1; 95{\%} confidence interval [CI], 1.0-1.2), with the strongest associations between weighted drug/alcohol use, drug/alcohol dependency risk, and antisocial/delinquent behavior and detection of HPV vaccine types (aOR 5 1.5; 95{\%} CI, 1.1-2.0) independent of number of recent sexual partners and vaccine dose (0-3). Conclusion: Increased HPV infections including HPV vaccine types were associated with greater number of psychosocial risk indicators even after controlling for demographics, sexual behavior, history of chlamydia, and vaccine dose.",
keywords = "Adolescent health, Alcohol, Drugs, HPV, Human papillomavirus, Psychosocial risk, Sexual activity",
author = "Linares, {Lourdes Oriana} and Shankar Viswanathan and Angela Diaz and Anne Nucci-Sack and Howard Strickler and Ken Peake and Jocelyn Weiss and Burk, {Robert D.} and Schlecht, {Nicolas F.}",
year = "2015",
language = "English (US)",
volume = "36",
pages = "620--627",
journal = "Journal of Developmental and Behavioral Pediatrics",
issn = "0196-206X",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Association between cumulative psychosocial risk and cervical human papillomavirus infection among female adolescents in a free vaccination program

AU - Linares, Lourdes Oriana

AU - Viswanathan, Shankar

AU - Diaz, Angela

AU - Nucci-Sack, Anne

AU - Strickler, Howard

AU - Peake, Ken

AU - Weiss, Jocelyn

AU - Burk, Robert D.

AU - Schlecht, Nicolas F.

PY - 2015

Y1 - 2015

N2 - Objective: This study investigated the association of cervical human papillomavirus (HPV) infection with cumulative psychosocial risk reflecting family disadvantage, psychological distress, and unhealthy lifestyle. Methods: The sample (N 5 745) comprised sexually active female adolescent patients (12-19 yr), primarily ethnic minorities, enrolled in a free HPV vaccination program. Subjects completed questionnaires and provided cervical swabs for HPV DNA testing. Unweighted and weighted principal component analyses for categorical data were used to derive multisystemic psychosocial risk indices using 9 indicators: low socioeconomic status, lack of adult involvement, not attending high school/college, history of treatment for depression/anxiety, antisocial/delinquent behavior, number of recent sexual partners, use of alcohol, use of drugs, and dependency risk for alcohol/drugs. The association between cervical HPV (any type, high-risk types, vaccine types) assayed by polymerase chain reaction and self-reported number of psychosocial risk indicators was estimated using multivariable logistic regression. Results: Subjects had a median of 3 psychosocial risk indicators. Multiple logistic regression analyses showed associations with unweighted and weighted number of psychosocial indicators for HPV any type (adjusted odds ratio [aOR] 5 1.1; 95% confidence interval [CI], 1.0-1.2), with the strongest associations between weighted drug/alcohol use, drug/alcohol dependency risk, and antisocial/delinquent behavior and detection of HPV vaccine types (aOR 5 1.5; 95% CI, 1.1-2.0) independent of number of recent sexual partners and vaccine dose (0-3). Conclusion: Increased HPV infections including HPV vaccine types were associated with greater number of psychosocial risk indicators even after controlling for demographics, sexual behavior, history of chlamydia, and vaccine dose.

AB - Objective: This study investigated the association of cervical human papillomavirus (HPV) infection with cumulative psychosocial risk reflecting family disadvantage, psychological distress, and unhealthy lifestyle. Methods: The sample (N 5 745) comprised sexually active female adolescent patients (12-19 yr), primarily ethnic minorities, enrolled in a free HPV vaccination program. Subjects completed questionnaires and provided cervical swabs for HPV DNA testing. Unweighted and weighted principal component analyses for categorical data were used to derive multisystemic psychosocial risk indices using 9 indicators: low socioeconomic status, lack of adult involvement, not attending high school/college, history of treatment for depression/anxiety, antisocial/delinquent behavior, number of recent sexual partners, use of alcohol, use of drugs, and dependency risk for alcohol/drugs. The association between cervical HPV (any type, high-risk types, vaccine types) assayed by polymerase chain reaction and self-reported number of psychosocial risk indicators was estimated using multivariable logistic regression. Results: Subjects had a median of 3 psychosocial risk indicators. Multiple logistic regression analyses showed associations with unweighted and weighted number of psychosocial indicators for HPV any type (adjusted odds ratio [aOR] 5 1.1; 95% confidence interval [CI], 1.0-1.2), with the strongest associations between weighted drug/alcohol use, drug/alcohol dependency risk, and antisocial/delinquent behavior and detection of HPV vaccine types (aOR 5 1.5; 95% CI, 1.1-2.0) independent of number of recent sexual partners and vaccine dose (0-3). Conclusion: Increased HPV infections including HPV vaccine types were associated with greater number of psychosocial risk indicators even after controlling for demographics, sexual behavior, history of chlamydia, and vaccine dose.

KW - Adolescent health

KW - Alcohol

KW - Drugs

KW - HPV

KW - Human papillomavirus

KW - Psychosocial risk

KW - Sexual activity

UR - http://www.scopus.com/inward/record.url?scp=84942746992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942746992&partnerID=8YFLogxK

M3 - Article

C2 - 25985216

AN - SCOPUS:84942746992

VL - 36

SP - 620

EP - 627

JO - Journal of Developmental and Behavioral Pediatrics

JF - Journal of Developmental and Behavioral Pediatrics

SN - 0196-206X

IS - 8

ER -